Mesenchymal stem cell for hemorrhagic stroke: A clinical review

IF 3.4 3区环境科学与生态学 Q3 CELL & TISSUE ENGINEERING

Regenerative Therapy Pub Date : 2025-06-12 DOI:10.1016/j.reth.2025.05.011

Silvia de la Calle , Mercedes Zurita

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Abstract

Hemorrhagic stroke, which is also called an intracerebral hemorrhage, is a cerebrovascular disease that represents a serious public health problem worldwide. Among all types of stroke, intracerebral hemorrhage causes the highest percentage of mortality and morbidity, affecting 2 million people annually, with no specific treatment established except for rehabilitation-oriented techniques.

In recent years, new alternatives have been sought to treat this type of pathology, with mesenchymal stem cell therapy gaining special relevance. These cells present a series of biological properties, including regenerative repair, neuroprotection, and immunomodulation that make them a tool with enormous potential in regenerative medicine. In this review, we are going to focus on clinical trials and clinical studies which use cell therapy with Mesenchymal Stem Cells as a treatment for patients suffering from intracerebral hemorrhage. The clinical trials found are not very numerous. It remains an area to be explored; however, existing studies suggest it is a safe therapy that yields positive neurological and functional outcomes in many treated patients. All of this makes it a very promising and encouraging therapy for patients with this type of pathology.

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间充质干细胞治疗出血性中风：临床回顾

出血性中风，也被称为脑出血，是一种脑血管疾病，是全球严重的公共卫生问题。在所有类型的中风中，脑出血导致的死亡率和发病率最高，每年影响200万人，除了以康复为导向的技术外，没有明确的治疗方法。近年来，新的选择已经寻求治疗这种类型的病理，与间充质干细胞治疗获得特殊的相关性。这些细胞表现出一系列的生物学特性，包括再生修复、神经保护和免疫调节，使它们成为再生医学中具有巨大潜力的工具。本文就间充质干细胞治疗脑出血的临床试验和临床研究作一综述。临床试验发现的数量并不多。这仍然是一个有待探索的领域；然而，现有的研究表明，这是一种安全的治疗方法，在许多接受治疗的患者中产生积极的神经和功能结果。所有这些都使它成为一种非常有希望和令人鼓舞的治疗方法，用于这种类型的病理患者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Regenerative Therapy Engineering-Biomedical Engineering

CiteScore

6.00

自引率

2.30%

发文量

106

审稿时长

49 days

期刊介绍： Regenerative Therapy is the official peer-reviewed online journal of the Japanese Society for Regenerative Medicine. Regenerative Therapy is a multidisciplinary journal that publishes original articles and reviews of basic research, clinical translation, industrial development, and regulatory issues focusing on stem cell biology, tissue engineering, and regenerative medicine.