Mamma MIA! Decidual NK cells involved in fetal neurodevelopment

IF 25.5 1区医学 Q1 IMMUNOLOGY

Immunity Pub Date : 2025-06-10 DOI:10.1016/j.immuni.2025.05.010

Norman Shreeve, Francesco Colucci

引用次数: 0

Abstract

Maternal immune activation (MIA) can cause neurodevelopmental disorders, but the underlying mechanisms are incompletely understood. In this issue of Immunity, Bian et al. show that MIA triggers decidual NK cells to secrete granzyme B, which crosses the placenta and disturbs microglial homeostasis in the fetal brain, leading to abnormal neurodevelopment.

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《妈妈咪呀!》蜕膜NK细胞参与胎儿神经发育

母体免疫激活（MIA）可引起神经发育障碍，但其潜在机制尚不完全清楚。在本期《免疫》杂志中，Bian等人发现MIA触发蜕膜NK细胞分泌颗粒酶B，颗粒酶B穿过胎盘，扰乱胎儿脑内小胶质稳态，导致神经发育异常。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunity 医学-免疫学

CiteScore

49.40

自引率

2.20%

发文量

205

审稿时长

6 months

期刊介绍： Immunity is a publication that focuses on publishing significant advancements in research related to immunology. We encourage the submission of studies that offer groundbreaking immunological discoveries, whether at the molecular, cellular, or whole organism level. Topics of interest encompass a wide range, such as cancer, infectious diseases, neuroimmunology, autoimmune diseases, allergies, mucosal immunity, metabolic diseases, and homeostasis.