Regio- and Stereoselective [3 + 2] cycloaddition of Isatogens with functionalized alkenes and its application to the synthesis of Halichrome A

IF 1.5 4区化学 Q3 CHEMISTRY, ORGANIC

Tetrahedron Letters Pub Date : 2025-04-26 DOI:10.1016/j.tetlet.2025.155626

Nanaka Ishihara , Ryu Fukuoka , Shinji Harada , Kenzo Yamatsugu , Shigeru Arai

引用次数: 0

Abstract

We investigated regio- and stereoselective [3 + 2] cycloaddition reactions of isatogens and found that various heteroatom-substituted CC double bonds are applicable to provide the corresponding heterocycles with regio- and stereoselective manner. Synthetic application of the products towards various heterocycles and the total synthesis of halichrome A is accomplished.

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功能化烯烃与异源物的区域和立体选择性[3 + 2]环加成及其在盐色胺A合成中的应用

我们研究了异动原的区域选择性和立体选择性[3 + 2]环加成反应，发现各种杂原子取代的CC双键都适用于提供相应的区域选择性和立体选择性的杂环。完成了产品在各种杂环化合物和盐铬酸盐A全合成中的合成应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tetrahedron Letters 化学-有机化学

CiteScore

3.50

自引率

5.60%

发文量

521

审稿时长

28 days

期刊介绍： Tetrahedron Letters provides maximum dissemination of outstanding developments in organic chemistry. The journal is published weekly and covers developments in techniques, structures, methods and conclusions in experimental and theoretical organic chemistry. Rapid publication of timely and significant research results enables researchers from all over the world to transmit quickly their new contributions to large, international audiences.