Front Cover: Fused Nitrogen Bridgehead N,O-Acetals as Versatile Scaffolds: Synthetic Strategies, Mechanism and Applications

IF 3.9 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemistry - A European Journal Pub Date : 2025-06-07 DOI:10.1002/chem.202583201

Alexis D. Kouvelas, Michael G. Kallitsakis, Ioannis N. Lykakis

引用次数: 0

Abstract

Fused nitrogen-bridgehead N,O-acetals are found as crucial scaffolds in natural products and biologically active compounds, exhibiting notable pharmaceutical potential. The Review by I. N. Lykakis and co-workers (DOI: 10.1002/chem.202500413) explores their synthetic methodologies, underlying mechanisms, and diverse applications, with a focus on the enantioselective synthesis of complex structures, especially hydropyrrolo-oxazole and oxazine derivatives, underscoring their significance in organic synthesis.

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前盖：熔融氮桥头堡N， o -缩醛作为多功能支架：合成策略，机理和应用

熔融氮桥头堡N， o -缩醛是天然产物和生物活性化合物的重要支架，具有显著的药用潜力。I. N. Lykakis及其同事的综述（DOI: 10.1002/chem.202500413）探讨了它们的合成方法，潜在机制和多种应用，重点关注复杂结构的对映选择性合成，特别是氢吡咯-恶唑和恶嗪衍生物，强调了它们在有机合成中的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemistry - A European Journal 化学-化学综合

CiteScore

7.90

自引率

4.70%

发文量

1808

审稿时长

1.8 months

期刊介绍： Chemistry—A European Journal is a truly international journal with top quality contributions (2018 ISI Impact Factor: 5.16). It publishes a wide range of outstanding Reviews, Minireviews, Concepts, Full Papers, and Communications from all areas of chemistry and related fields. Based in Europe Chemistry—A European Journal provides an excellent platform for increasing the visibility of European chemistry as well as for featuring the best research from authors from around the world. All manuscripts are peer-reviewed, and electronic processing ensures accurate reproduction of text and data, plus short publication times. The Concepts section provides nonspecialist readers with a useful conceptual guide to unfamiliar areas and experts with new angles on familiar problems. Chemistry—A European Journal is published on behalf of ChemPubSoc Europe, a group of 16 national chemical societies from within Europe, and supported by the Asian Chemical Editorial Societies. The ChemPubSoc Europe family comprises: Angewandte Chemie, Chemistry—A European Journal, European Journal of Organic Chemistry, European Journal of Inorganic Chemistry, ChemPhysChem, ChemBioChem, ChemMedChem, ChemCatChem, ChemSusChem, ChemPlusChem, ChemElectroChem, and ChemistryOpen.