Quantitative Assessment of Spinal Cord Injury in Cervical Spondylotic Myelopathy: A Comparison Study of MAGiC and MUSE-DTI

IF 3.2 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

European Journal of Radiology Pub Date : 2025-06-04 DOI:10.1016/j.ejrad.2025.112214

Shuting Huang , Haoyue Shao , Qiufeng Liu , Weiyin Vivian Liu , Qiya Zhang , Longyu Deng , Chaoxu Liu , Deeq Mohamed Omar , Xiangyu Tang

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引用次数: 0

Abstract

Objectives

To compare synthetic magnetic resonance imaging (MAGnetic resonance image Compilation, MAGiC) and MUSE-DTI (MUltiplexed Sensitivity Encoding-Diffusion Tensor Imaging) in determining the severity of spinal cord injury in cervical spondylotic myelopathy (CSM).

Methods

All subjects (69 CSM subjects and 15 controls) underwent synthetic MRI and MUSE-DTI scans. Japanese Orthopaedic Association (JOA) score was evaluated preoperatively. Cervical canal stenosis degree was graded 0-Ⅲ using an MRI grading system. Twelve patients received surgical intervention and JOA evaluation 1 year after operation. Regions of interest covered the whole spinal cord at the maximal compression level (MCL) and C2 vertebral level to generate T1, T2 and PD values from synthetic quantitative map and fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD), and radial diffusivity (RD) values from MUSE-DTI map.

Results

AD_MCL values demonstrated higher sensitivity to spinal microstructural changes than other parameters, increasing from Grade Ⅰ-Ⅲ and decreasing at Grade Ⅰ compared to Grade 0 (P < 0.05). FA_MCL and T1_MCL values decreased from Grade 0-Ⅱ. Furthermore, AD_C2 values in Grade I were significantly lower than Grade 0 (P = 0.005). FA_C2 values correlated with the minimum FA values of multi-segment compressed spinal cord (P = 0.007). All MUSE-DTI parameters at MCL correlated with JOA scores across all grades. The preoperative AD_MCL values correlated with postoperative recovery rate, whereas MAGiC-derived parameters did not.

Conclusion

MUSE-DTI parameters better reflected microstructural alterations and secondary damages of spinal cord and correlated with the JOA scores and postoperative recovery rate. Therefore, MUSE-DTI could provide more quantitative information to evaluate the severity of spinal cord injury in CSM.

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颈椎病脊髓损伤的定量评估：MAGiC与MUSE-DTI的比较研究

目的比较磁共振合成成像（magnetic resonance image Compilation, MAGiC）与musi - dti （MUltiplexed Sensitivity coded - diffusion Tensor imaging, MUSE-DTI）对脊髓型颈椎病（CSM）脊髓损伤严重程度的判断价值。方法所有患者（69例CSM组，15例对照组）均行MRI合成扫描和MUSE-DTI扫描。术前评估日本骨科协会（JOA）评分。颈椎管狭窄程度采用MRI分级系统分级0-Ⅲ。12例患者术后1年接受手术干预和JOA评估。感兴趣的区域覆盖了整个脊髓的最大压缩水平（MCL）和C2椎体水平，从合成定量图和分数各向异性（FA）、平均扩散率（MD）、轴向扩散率（AD）和径向扩散率（RD）的MUSE-DTI图中生成T1、T2和PD值。结果与其他参数相比，admcl值对脊柱微结构变化的敏感性更高，从Ⅰ-Ⅲ级开始升高，Ⅰ级与0级相比降低(P <；0.05)。FAMCL和T1MCL值从0级开始下降-Ⅱ。分级1的ADC2值显著低于分级0 （P = 0.005）。多节段受压脊髓的FAC2值与最小FA值相关（P = 0.007）。MCL的所有MUSE-DTI参数与所有年级的JOA分数相关。术前ADMCL值与术后恢复率相关，而magic衍生参数不相关。结论muse - dti参数较好地反映了脊髓的微结构改变和继发性损伤，并与JOA评分和术后恢复率相关。因此，MUSE-DTI可以为CSM脊髓损伤的严重程度提供更定量的信息。

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来源期刊

European Journal of Radiology 医学-核医学

CiteScore

6.70

自引率

3.00%

发文量

398

审稿时长

42 days

期刊介绍： European Journal of Radiology is an international journal which aims to communicate to its readers, state-of-the-art information on imaging developments in the form of high quality original research articles and timely reviews on current developments in the field. Its audience includes clinicians at all levels of training including radiology trainees, newly qualified imaging specialists and the experienced radiologist. Its aim is to inform efficient, appropriate and evidence-based imaging practice to the benefit of patients worldwide.