Tasneem Bux, Kyle Pillay, Reyna Daya, Zaheer Bayat, Lara S Greenstein
{"title":"An uncommon variant of Alzheimer's disease: Posterior cortical atrophy.","authors":"Tasneem Bux, Kyle Pillay, Reyna Daya, Zaheer Bayat, Lara S Greenstein","doi":"10.4102/sajpsychiatry.v31i0.2420","DOIUrl":null,"url":null,"abstract":"<p><strong>Introduction: </strong>This case report highlights one of the less common variants of major neurocognitive disorder because of Alzheimer's disease, posterior cortical atrophy. There is a paucity of data about this condition in sub-Saharan Africa.</p><p><strong>Patient presentation: </strong>A 54-year-old female presented to the geriatric clinic following a 2-year history of poor memory and inability to fulfil her work obligations. The most prominent symptom was visual disturbance, with a normal ophthalmic examination.</p><p><strong>Management and outcome: </strong>Workup done to reveal reversible causes of dementia did not yield any positive results. After a full history, physical and cognitive examination and radiological investigations, a diagnosis of posterior cortical atrophy variant of major neurocognitive disorder because of Alzheimer's disease as the most likely aetiology was established.</p><p><strong>Conclusion: </strong>Posterior cortical atrophy is a rare variant of Alzheimer's disease, and no case reports from South Africa are available in the literature.</p><p><strong>Contribution: </strong>This case reminds us that unusual presentations of cognitive impairment require a broad differential diagnosis.</p>","PeriodicalId":51156,"journal":{"name":"South African Journal of Psychiatry","volume":"31 ","pages":"2420"},"PeriodicalIF":1.3000,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12135714/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"South African Journal of Psychiatry","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4102/sajpsychiatry.v31i0.2420","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q4","JCRName":"PSYCHIATRY","Score":null,"Total":0}
引用次数: 0
Abstract
Introduction: This case report highlights one of the less common variants of major neurocognitive disorder because of Alzheimer's disease, posterior cortical atrophy. There is a paucity of data about this condition in sub-Saharan Africa.
Patient presentation: A 54-year-old female presented to the geriatric clinic following a 2-year history of poor memory and inability to fulfil her work obligations. The most prominent symptom was visual disturbance, with a normal ophthalmic examination.
Management and outcome: Workup done to reveal reversible causes of dementia did not yield any positive results. After a full history, physical and cognitive examination and radiological investigations, a diagnosis of posterior cortical atrophy variant of major neurocognitive disorder because of Alzheimer's disease as the most likely aetiology was established.
Conclusion: Posterior cortical atrophy is a rare variant of Alzheimer's disease, and no case reports from South Africa are available in the literature.
Contribution: This case reminds us that unusual presentations of cognitive impairment require a broad differential diagnosis.
期刊介绍:
The journal is the leading psychiatric journal of Africa. It provides open-access scholarly reading for psychiatrists, clinical psychologists and all with an interest in mental health. It carries empirical and conceptual research articles, reviews, editorials, and scientific letters related to psychiatry. It publishes work from various places in the world, and makes special provision for the interests of Africa. It seeks to serve its readership and researchers with the most topical content in psychiatry for clinical practice and academic pursuits, including work in the subspecialty areas of psychiatry.