An uncommon variant of Alzheimer's disease: Posterior cortical atrophy.

IF 1.3 4区 医学 Q4 PSYCHIATRY
South African Journal of Psychiatry Pub Date : 2025-05-23 eCollection Date: 2025-01-01 DOI:10.4102/sajpsychiatry.v31i0.2420
Tasneem Bux, Kyle Pillay, Reyna Daya, Zaheer Bayat, Lara S Greenstein
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引用次数: 0

Abstract

Introduction: This case report highlights one of the less common variants of major neurocognitive disorder because of Alzheimer's disease, posterior cortical atrophy. There is a paucity of data about this condition in sub-Saharan Africa.

Patient presentation: A 54-year-old female presented to the geriatric clinic following a 2-year history of poor memory and inability to fulfil her work obligations. The most prominent symptom was visual disturbance, with a normal ophthalmic examination.

Management and outcome: Workup done to reveal reversible causes of dementia did not yield any positive results. After a full history, physical and cognitive examination and radiological investigations, a diagnosis of posterior cortical atrophy variant of major neurocognitive disorder because of Alzheimer's disease as the most likely aetiology was established.

Conclusion: Posterior cortical atrophy is a rare variant of Alzheimer's disease, and no case reports from South Africa are available in the literature.

Contribution: This case reminds us that unusual presentations of cognitive impairment require a broad differential diagnosis.

阿尔茨海默病的一种罕见变体:后皮质萎缩。
本病例报告强调了由阿尔茨海默病引起的主要神经认知障碍的一种不太常见的变体,即后皮层萎缩。关于撒哈拉以南非洲地区这种情况的数据缺乏。患者介绍:一名54岁女性,因2年的记忆力差和无法履行工作义务而来到老年诊所。最突出的症状是视力障碍,眼科检查正常。管理和结果:为揭示痴呆的可逆原因所做的检查没有产生任何积极的结果。经过完整的病史,体格和认知检查以及影像学调查,诊断为阿尔茨海默病引起的主要神经认知障碍的后皮质萎缩变异体是最可能的病因。结论:后皮层萎缩是一种罕见的阿尔茨海默病的变体,在文献中没有来自南非的病例报告。贡献:本病例提醒我们,认知障碍的不寻常表现需要广泛的鉴别诊断。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
1.60
自引率
10.00%
发文量
56
审稿时长
>12 weeks
期刊介绍: The journal is the leading psychiatric journal of Africa. It provides open-access scholarly reading for psychiatrists, clinical psychologists and all with an interest in mental health. It carries empirical and conceptual research articles, reviews, editorials, and scientific letters related to psychiatry. It publishes work from various places in the world, and makes special provision for the interests of Africa. It seeks to serve its readership and researchers with the most topical content in psychiatry for clinical practice and academic pursuits, including work in the subspecialty areas of psychiatry.
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