A new compound with biological activities purified from Fusarium oxysporum LZC03.

IF 1.6 3区化学 Q3 CHEMISTRY, APPLIED

Natural Product Research Pub Date : 2025-06-05 DOI:10.1080/14786419.2025.2514259

Bing Liu, Ting Zhu, Ruiyang Lu, Yuxin Wang, Xue Tian, Yuchen Liu, Ning Chen, Ying Xu

{"title":"A new compound with biological activities purified from Fusarium oxysporum LZC03.","authors":"Bing Liu, Ting Zhu, Ruiyang Lu, Yuxin Wang, Xue Tian, Yuchen Liu, Ning Chen, Ying Xu","doi":"10.1080/14786419.2025.2514259","DOIUrl":null,"url":null,"abstract":"In recent years, the study of endophytic fungi in traditional Chinese medicine has been drawing more and more attention from scholars around the globe. Secondary metabolites derived from these fungi have emerged as a rich source for uncovering structurally unique lead compounds. Strain LZC03 was obtained from freshly harvested common sage herb in Huangshan, Anhui Province, China. Through comprehensive morphological and molecular taxonomic analyses, it was determined to be Fusarium oxysporum. A novel compound, methyl 2-(4-((3-methylbut-2-en-1-yl)oxy)phenyl)acetyl)glycinate (1), together with a known compound, alternariol (2), were isolated and purified from the n-butanol fraction of the LZC03 fermentation product. Their structures were elucidated using 1D, 2D NMR and HRESI-MS techniques. The antioxidant and cytotoxic properties of both compounds were investigated. The findings indicated that both compound 1 and 2 exhibited cytotoxic and antioxidant capabilities. Compound 1 exhibited strong cytotoxicity and moderate antioxidant activity.","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-9"},"PeriodicalIF":1.6000,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2025.2514259","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}

引用次数: 0

Abstract

In recent years, the study of endophytic fungi in traditional Chinese medicine has been drawing more and more attention from scholars around the globe. Secondary metabolites derived from these fungi have emerged as a rich source for uncovering structurally unique lead compounds. Strain LZC03 was obtained from freshly harvested common sage herb in Huangshan, Anhui Province, China. Through comprehensive morphological and molecular taxonomic analyses, it was determined to be Fusarium oxysporum. A novel compound, methyl 2-(4-((3-methylbut-2-en-1-yl)oxy)phenyl)acetyl)glycinate (1), together with a known compound, alternariol (2), were isolated and purified from the n-butanol fraction of the LZC03 fermentation product. Their structures were elucidated using 1D, 2D NMR and HRESI-MS techniques. The antioxidant and cytotoxic properties of both compounds were investigated. The findings indicated that both compound 1 and 2 exhibited cytotoxic and antioxidant capabilities. Compound 1 exhibited strong cytotoxicity and moderate antioxidant activity.

查看原文本刊更多论文

从尖孢镰刀菌LZC03中纯化出具有生物活性的新化合物。

近年来，中药内生真菌的研究越来越受到国内外学者的关注。来源于这些真菌的次生代谢物已成为揭示结构独特的先导化合物的丰富来源。菌株LZC03是从安徽黄山新鲜收获的鼠尾草中分离得到的。经形态学和分子分类学综合分析，确定为尖孢镰刀菌。从LZC03发酵产物的正丁醇馏分中分离纯化了一个新的化合物2-（4-（（3-甲基-2-烯-1-基）氧）苯基）乙酰基)甘氨酸甲酯(1)和一个已知的化合物alternariol(2)。利用一维、二维NMR和HRESI-MS技术对其结构进行了表征。研究了两种化合物的抗氧化和细胞毒性。结果表明，化合物1和2均具有细胞毒性和抗氧化能力。化合物1具有较强的细胞毒性和中等的抗氧化活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Natural Product Research 化学-医药化学

CiteScore

5.10

自引率

9.10%

发文量

605

审稿时长

2.1 months

期刊介绍： The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds. The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal. Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section. All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.