Systemic capillary leak syndrome associated with smouldering multiple myeloma treated by bortezomib plus dexamethasone: A case report.

Abstract

Monoclonal gammopathy-capillary leak syndrome (MG-CLS) is a rare disorder characterized by recurrent hypotension, edema and multiple organ dysfunction in the presence of serum monoclonal immunoglobulin. Here, we present a case of MG-CLS associated with smoldering multiple myeloma with three acute attacks. The patient was treated with plasma cell-directed chemotherapy including bortezomib and dexamethasone. No evidence of recurrence was observed during a 10-month follow-up. The combination of anti-plasma cell therapy provides a potential approach to manage MG-CLS and reduce the incidence of acute episodes.