Histone Deacetylase 6 (HDAC6) in Ciliopathies: Emerging Insights and Therapeutic Implications (Adv. Sci. 21/2025)

IF 14.1 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Advanced Science Pub Date : 2025-06-05 DOI:10.1002/advs.202570163

Zhiyi Wang, Xiaofan Zhu, Zhenzhou Huang, Kaidi Ren, Jie Ran, Yang Yang

引用次数: 0

Abstract

Histone Deacetylase 6 in Ciliopathies

HDAC6's dual role in ciliopathies is portrayed through Nezha, symbolizing its complex regulatory function in ciliary dynamics. Merging mythology with science, the image highlights HDAC6's influence on cilia-related signaling and disease progression, and the therapeutic promise of selective inhibitors in restoring ciliary integrity and maintaining cellular homeostasis. More details can be found in article number 2412921 by Kaidi Ren, Jie Ran, Yang Yang, and co-workers.

Abstract Image

查看原文本刊更多论文

组蛋白去乙酰化酶6 （HDAC6）在纤毛病中的作用：新见解和治疗意义（Adv. Sci. 21/2025）

组蛋白去乙酰化酶6在纤毛病中的作用hdac6在纤毛病中的双重作用通过哪吒被描绘出来，象征着它在纤毛动力学中的复杂调节功能。将神话与科学相结合，该图像突出了HDAC6对纤毛相关信号传导和疾病进展的影响，以及选择性抑制剂在恢复纤毛完整性和维持细胞稳态方面的治疗前景。更多细节可以在任凯迪、冉洁、杨洋及其同事的2412921号文章中找到。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Advanced Science CHEMISTRY, MULTIDISCIPLINARYNANOSCIENCE &-NANOSCIENCE & NANOTECHNOLOGY

CiteScore

18.90

自引率

2.60%

发文量

1602

审稿时长

1.9 months

期刊介绍： Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.