A new era in regenerative medicine: Cell replacement therapy for Parkinson’s disease is on the horizon

IF 19.8 1区医学 Q1 CELL & TISSUE ENGINEERING

Cell stem cell Pub Date : 2025-06-05 DOI:10.1016/j.stem.2025.05.005

Young Cha, Pierre Leblanc, Kwang-Soo Kim

引用次数: 0

Abstract

Parkinson’s disease (PD), characterized by the selective loss of midbrain dopaminergic neurons (mDANs), is a promising target for cell replacement therapy. Two recent clinical trials¹^,² published in Nature report the safety and potential efficacy of human pluripotent stem cell-based approaches, representing a major milestone in regenerative medicine for PD.

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再生医学的新时代：帕金森病的细胞替代疗法即将到来

帕金森病（PD）以中脑多巴胺能神经元（mdan）的选择性丧失为特征，是细胞替代治疗的一个有希望的靶点。最近发表在《自然》杂志上的两项临床试验1,2报告了基于人类多能干细胞的方法的安全性和潜在有效性，代表了PD再生医学的一个重要里程碑。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell stem cell 生物-细胞生物学

CiteScore

37.10

自引率

2.50%

发文量

151

审稿时长

42 days

期刊介绍： Cell Stem Cell is a comprehensive journal covering the entire spectrum of stem cell biology. It encompasses various topics, including embryonic stem cells, pluripotency, germline stem cells, tissue-specific stem cells, differentiation, epigenetics, genomics, cancer stem cells, stem cell niches, disease models, nuclear transfer technology, bioengineering, drug discovery, in vivo imaging, therapeutic applications, regenerative medicine, clinical insights, research policies, ethical considerations, and technical innovations. The journal welcomes studies from any model system providing insights into stem cell biology, with a focus on human stem cells. It publishes research reports of significant importance, along with review and analysis articles covering diverse aspects of stem cell research.