Exploring the role of palmitoylation in sepsis: mechanistic insights and future perspectives.

IF 6.4 2区 医学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY
Susu Cao, Wenyan Xiao, Sinong Pan, Tianfeng Hua, Min Yang
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引用次数: 0

Abstract

Background: The palmitoylation system is intricate, multidimensional, and plays a crucial role in various inflammatory and immune-related disorders. Palmitoylation controls protein stability, cargo sorting, signal transmission, as well as cell differentiation and death. Notably, a growing body of studies has highlighted its participation in inflammatory processes, either directly or indirectly, indicating its broad and complex involvement in the development of sepsis. Understanding the mechanisms underlying palmitoylation is essential for advancing research on sepsis. We began this review with a brief summary of research related to sepsis progression. Second, we went over recent studies on palmitoylation. Third, we compiled and described palmitoylation-related alterations in vital molecules or biological processes involved in sepsis. Lastly, we outlined the promising features of palmitoylation and proposed a hopeful outlook for future research in sepsis.

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探索棕榈酰化在败血症中的作用:机制的见解和未来的观点。
背景:棕榈酰化系统是复杂的、多维的,在各种炎症和免疫相关疾病中起着至关重要的作用。棕榈酰化控制蛋白质稳定性、货物分类、信号传递以及细胞分化和死亡。值得注意的是,越来越多的研究强调其直接或间接参与炎症过程,表明其在脓毒症的发展中广泛而复杂的参与。了解棕榈酰化的机制对于推进败血症的研究至关重要。我们首先对与败血症进展相关的研究进行简要总结。其次,我们回顾了最近关于棕榈酰化的研究。第三,我们编译并描述了与败血症相关的重要分子或生物过程中棕榈酰化相关的改变。最后,我们概述了棕榈酰化的前景特征,并对败血症的未来研究提出了充满希望的展望。
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来源期刊
Molecular Medicine
Molecular Medicine 医学-生化与分子生物学
CiteScore
8.60
自引率
0.00%
发文量
137
审稿时长
1 months
期刊介绍: Molecular Medicine is an open access journal that focuses on publishing recent findings related to disease pathogenesis at the molecular or physiological level. These insights can potentially contribute to the development of specific tools for disease diagnosis, treatment, or prevention. The journal considers manuscripts that present material pertinent to the genetic, molecular, or cellular underpinnings of critical physiological or disease processes. Submissions to Molecular Medicine are expected to elucidate the broader implications of the research findings for human disease and medicine in a manner that is accessible to a wide audience.
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