Leptols A and B, one meroterpenoid and one coumarin hybrid from the leaves of Melicope pteleifolia and its anti-inflammation in BV2 cells.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-06-04 DOI:10.1080/10286020.2025.2509767

He-Lin Wei, Jing-Jing Sun, Jia-Qi Chen, Tao Wang, Jun Li, Peng-Fei Tu

引用次数: 0

Abstract

One meroterpenoid and one coumarin hybrid, namely leptols A (1) and B (2), respectively, and seven known chromone analogues have been isolated from the leaves of Melicope pteleifolia. The structures were elucidated on the basis of spectroscopic methods (UV, IR, HRMS, and NMR), and the absolute configuration was determined by comparing its experimental and calculated OR values. These isolates were evaluated for anti-inflammatory activities on the lipopolysaccharide (LPS) induced nitric oxide (NO) production in BV2 microglial cells, and compound 1 exhibited potential nitric oxide inhibitory activities with IC₅₀ value of 12.0 µM.

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百里果叶片瘦素A、B、甲硫萜类和香豆素杂种化合物及其对BV2细胞的抗炎作用。

从百乐叶中分离到1个萜类化合物A(1)和1个香豆素化合物B(2)，以及7个已知的色素类似物。利用紫外、红外、HRMS和核磁共振等光谱方法对其结构进行了鉴定，并通过比较其实验值和计算值确定了其绝对构型。这些分离物对脂多糖（LPS）诱导的BV2小胶质细胞一氧化氮（NO）产生的抗炎活性进行了评估，化合物1显示出潜在的一氧化氮抑制活性，IC50值为12.0µM。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.