Prenatal, Perinatal, and Postnatal Factors in a Cohort of Very Preterm and Very Low Birth Weight Toddlers with Suspected Autism Spectrum Disorder.

IF 3.2 2区心理学 Q1 PSYCHOLOGY, DEVELOPMENTAL

Journal of Autism and Developmental Disorders Pub Date : 2025-06-04 DOI:10.1007/s10803-025-06897-7

Marta Marín Soro, Laura Gisbert Gustemps, Héctor Boix Alonso, Sergi Martínez-Maldonado, Ricard Coronado Contreras

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Abstract

There is growing interest in the identification of prenatal, perinatal, and postnatal factors that correlate with autism spectrum disorders (ASD) and these have been extensively studied in the general population. This study aimed to investigate the relationship between these factors and the elevated likelihood of being diagnosed with ASD in the very preterm and very low birth weight population. Conducted as a prospective longitudinal study, this research monitored 133 neonates born very preterm (less than 32 weeks of gestation) or weighing less than 1,500 g at birth from birth until 2 years of age. Having a mother born abroad, low gestational age, bronchopulmonary dysplasia, hearing loss, longer NICU stay and low Apgar score of 10 min were associated with an increase in suspected ASD. Conversely, cesarean delivery, and full-dose corticosteroid maturation were associated with a lower incidence of ASD. Some factors associated with ASD in the very preterm population may differ from those found in the general population. Large-scale studies with longitudinal datasets are warranted.

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疑似自闭症谱系障碍的极早产儿和极低出生体重幼儿的产前、围产期和产后因素。

人们对确定与自闭症谱系障碍（ASD）相关的产前、围产期和产后因素越来越感兴趣，这些因素在一般人群中得到了广泛的研究。本研究旨在调查这些因素与极早产和极低出生体重人群中被诊断为ASD的可能性升高之间的关系。作为一项前瞻性纵向研究，本研究监测了133名极早产（少于32周妊娠）或出生时体重低于1500克的新生儿从出生到2岁。母亲在国外出生、胎龄低、支气管肺发育不良、听力损失、新生儿重症监护病房停留时间较长和Apgar评分低（10分钟）与疑似ASD的增加有关。相反，剖宫产和全剂量皮质类固醇成熟与较低的ASD发病率相关。在极早产人群中与ASD相关的一些因素可能与在一般人群中发现的因素不同。有必要进行纵向数据集的大规模研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Autism and Developmental Disorders PSYCHOLOGY, DEVELOPMENTAL-

CiteScore

8.00

自引率

10.30%

发文量

433

期刊介绍： The Journal of Autism and Developmental Disorders seeks to advance theoretical and applied research as well as examine and evaluate clinical diagnoses and treatments for autism and related disabilities. JADD encourages research submissions on the causes of ASDs and related disorders, including genetic, immunological, and environmental factors; diagnosis and assessment tools (e.g., for early detection as well as behavioral and communications characteristics); and prevention and treatment options. Sample topics include: Social responsiveness in young children with autism Advances in diagnosing and reporting autism Omega-3 fatty acids to treat autism symptoms Parental and child adherence to behavioral and medical treatments for autism Increasing independent task completion by students with autism spectrum disorder Does laughter differ in children with autism? Predicting ASD diagnosis and social impairment in younger siblings of children with autism The effects of psychotropic and nonpsychotropic medication with adolescents and adults with ASD Increasing independence for individuals with ASDs Group interventions to promote social skills in school-aged children with ASDs Standard diagnostic measures for ASDs Substance abuse in adults with autism Differentiating between ADHD and autism symptoms Social competence and social skills training and interventions for children with ASDs Therapeutic horseback riding and social functioning in children with autism Authors and readers of the Journal of Autism and Developmental Disorders include sch olars, researchers, professionals, policy makers, and graduate students from a broad range of cross-disciplines, including developmental, clinical child, and school psychology; pediatrics; psychiatry; education; social work and counseling; speech, communication, and physical therapy; medicine and neuroscience; and public health.