First-line treatment with a combination of immunotherapy, anti-EGFR monoclonal antibodies, and chemotherapeutics for unresectable left KRAS/BRAF wild-type microsatellite-stable colorectal cancer: a case report.

IF 2.2 4区 医学 Q3 ONCOLOGY
Anti-Cancer Drugs Pub Date : 2025-09-01 Epub Date: 2025-06-04 DOI:10.1097/CAD.0000000000001736
Yaoyi Zhang, Dongfeng Wang, Ke Zhang, Sheng Li, Chen Yu
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引用次数: 0

Abstract

Immunotherapy shows limited efficacy in microsatellite-stable (MSS) colorectal cancer. This case report describes a 40-year-old male with left-sided kirsten rat sarcoma viral oncogene homolog (KRAS)/v-raf murine sarcoma viral oncogene homolog B (BRAF) wild-type, MSS colorectal cancer and liver metastases who achieved complete regression of metastases following first-line treatment with toripalimab, cetuximab, and FOLFIRI (irinotecan + fluorouracil + leucovorin), enabling curative-intent surgical resection. The patient achieved a progression-free survival of 16 months and an overall survival exceeding 20 months. The regimen demonstrated excellent tolerability without severe adverse events, suggesting that this triple combination represents a promising strategy for conversion therapy in advanced MSS colorectal cancer.

免疫治疗、抗egfr单克隆抗体和化疗联合一线治疗不可切除的左侧KRAS/BRAF野生型微卫星稳定型结直肠癌:1例报告
免疫疗法对微卫星稳定型(MSS)结直肠癌的疗效有限。本病例报告描述了一名患有左侧kirsten大鼠肉瘤病毒癌基因同源物(KRAS)/v-raf小鼠肉瘤病毒癌基因同源物B (BRAF)野生型、MSS结直肠癌和肝转移的40岁男性患者,在接受托利帕利单抗、西妥昔单抗和FOLFIRI(伊立替康+氟尿嘧啶+亚叶酸钙)的一线治疗后,转移完全消退,能够进行治愈性手术切除。患者的无进展生存期为16个月,总生存期超过20个月。该方案显示出良好的耐受性,没有严重的不良事件,表明这种三联疗法代表了晚期MSS结直肠癌转换治疗的有希望的策略。
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来源期刊
Anti-Cancer Drugs
Anti-Cancer Drugs 医学-药学
CiteScore
3.80
自引率
0.00%
发文量
244
审稿时长
3 months
期刊介绍: Anti-Cancer Drugs reports both clinical and experimental results related to anti-cancer drugs, and welcomes contributions on anti-cancer drug design, drug delivery, pharmacology, hormonal and biological modalities and chemotherapy evaluation. An internationally refereed journal devoted to the fast publication of innovative investigations on therapeutic agents against cancer, Anti-Cancer Drugs aims to stimulate and report research on both toxic and non-toxic anti-cancer agents. Consequently, the scope on the journal will cover both conventional cytotoxic chemotherapy and hormonal or biological response modalities such as interleukins and immunotherapy. Submitted articles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.
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