The role and mechanisms of RNA-binding proteins in the development of ovarian aging and related diseases

IF 5.1 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL

Life sciences Pub Date : 2025-06-04 DOI:10.1016/j.lfs.2025.123792

Wenjia Luo , Chunxia Huang , Ke Sun , Kangping Yang , Jiaqiang Wu , Liang Yang

引用次数: 0

Abstract

Ovarian aging is a key factor influencing female fertility and overall health. RNA-binding proteins (RBPs) regulate mRNA stability and translation, playing a significant role in maintaining ovarian function. This review discusses RBPs' involvement in oocyte development, folliculogenesis, and ovarian homeostasis. Additionally, we explore their roles in ovarian aging-related diseases and potential strategies for mitigating ovarian decline by targeting RBP activity. This review highlights RBPs' molecular mechanisms and potential applications for understanding and treating ovarian aging.

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rna结合蛋白在卵巢衰老及相关疾病发生中的作用及机制

卵巢老化是影响女性生育能力和整体健康的关键因素。rna结合蛋白（rbp）调控mRNA的稳定性和翻译，在维持卵巢功能中发挥重要作用。本文就rbp在卵母细胞发育、卵泡发生和卵巢稳态中的作用作一综述。此外，我们还探讨了它们在卵巢衰老相关疾病中的作用，以及通过靶向RBP活性来减轻卵巢衰退的潜在策略。本文综述了rbp的分子机制及其在了解和治疗卵巢衰老方面的潜在应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Life sciences 医学-药学

CiteScore

12.20

自引率

1.60%

发文量

841

审稿时长

6 months

期刊介绍： Life Sciences is an international journal publishing articles that emphasize the molecular, cellular, and functional basis of therapy. The journal emphasizes the understanding of mechanism that is relevant to all aspects of human disease and translation to patients. All articles are rigorously reviewed. The Journal favors publication of full-length papers where modern scientific technologies are used to explain molecular, cellular and physiological mechanisms. Articles that merely report observations are rarely accepted. Recommendations from the Declaration of Helsinki or NIH guidelines for care and use of laboratory animals must be adhered to. Articles should be written at a level accessible to readers who are non-specialists in the topic of the article themselves, but who are interested in the research. The Journal welcomes reviews on topics of wide interest to investigators in the life sciences. We particularly encourage submission of brief, focused reviews containing high-quality artwork and require the use of mechanistic summary diagrams.