Therapeutic roles of natural and engineered mesenchymal stem cells and extracellular vesicles in atopic dermatitis

IF 3.5 3区环境科学与生态学 Q3 CELL & TISSUE ENGINEERING

Regenerative Therapy Pub Date : 2025-06-04 DOI:10.1016/j.reth.2025.05.009

Tingting Ren , Kang He , Donghua Xu , Yuxiang Kong , Shuyue Jiang , Jinjin Chu , Yi Sun , Jie Zang , Zhenhua Wang

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引用次数: 0

Abstract

Atopic dermatitis (AD) is a chronic and inflammatory disease characterized by skin barrier destruction, sustained inflammation, and immune imbalance. Increasing evidence has suggested mesenchymal stem cells (MSCs) exhibit great potentials in treating AD due to the strong anti-inflammatory, immunomodulatory, and regenerative repair properties. As a cell-free nanocarrier, MSC-derived extracellular vesicles (MSC-EVs) play critical roles in mediating intercellular communications. Recent advance has suggested some bioengineering strategies have greatly improved the therapeutic potentials of MSCs and MSC-EVs in AD treatment, such as genetic reprogramming, biomimetic scaffold integration, and precision surface functionalization. In this comprehensive review, we systematically evaluate the current landscape of both natural and engineered MSCs and MSC-EVs to provide updated insights into the exploration of therapeutic strategies for AD.

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自然和工程间充质干细胞和细胞外囊泡在特应性皮炎中的治疗作用

特应性皮炎（AD）是一种以皮肤屏障破坏、持续炎症和免疫失衡为特征的慢性炎症性疾病。越来越多的证据表明，间充质干细胞（MSCs）由于其强大的抗炎、免疫调节和再生修复特性，在治疗阿尔茨海默病方面具有巨大的潜力。作为一种无细胞的纳米载体，间充质干细胞衍生的细胞外囊泡（msc - ev）在介导细胞间通讯中起着关键作用。最近的研究进展表明，一些生物工程策略极大地提高了MSCs和msc - ev在AD治疗中的治疗潜力，如基因重编程、仿生支架整合和精确表面功能化。在这篇全面的综述中，我们系统地评估了天然和工程MSCs以及msc - ev的现状，为探索阿尔茨海默病的治疗策略提供了最新的见解。

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来源期刊

Regenerative Therapy Engineering-Biomedical Engineering

CiteScore

6.00

自引率

2.30%

发文量

106

审稿时长

49 days

期刊介绍： Regenerative Therapy is the official peer-reviewed online journal of the Japanese Society for Regenerative Medicine. Regenerative Therapy is a multidisciplinary journal that publishes original articles and reviews of basic research, clinical translation, industrial development, and regulatory issues focusing on stem cell biology, tissue engineering, and regenerative medicine.