CROSsing the Rubicon: Brainstem peroxide levels drive sleep-wake dynamics

IF 27.7 1区生物学 Q1 CELL BIOLOGY

Cell metabolism Pub Date : 2025-06-03 DOI:10.1016/j.cmet.2025.05.005

Nicole M. Gilette, Jonathan O. Lipton

引用次数: 0

Abstract

A crucial goal of sleep science is to uncover the molecular mechanisms that translate sleep need into neural pathways that discharge sleep/wake transitions. In a new study, Tian et al.¹ provide support in living animals that peroxide in the substantia nigra is a critical driver of these states.

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跨越卢比孔河：脑干过氧化氢水平驱动睡眠-觉醒动力学

睡眠科学的一个关键目标是揭示将睡眠需求转化为释放睡眠/觉醒转换的神经通路的分子机制。在一项新的研究中，Tian等人1在活体动物中提供了支持，即黑质中的过氧化物是这些状态的关键驱动因素。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell metabolism 生物-内分泌学与代谢

CiteScore

48.60

自引率

1.40%

发文量

173

审稿时长

2.5 months

期刊介绍： Cell Metabolism is a top research journal established in 2005 that focuses on publishing original and impactful papers in the field of metabolic research.It covers a wide range of topics including diabetes, obesity, cardiovascular biology, aging and stress responses, circadian biology, and many others. Cell Metabolism aims to contribute to the advancement of metabolic research by providing a platform for the publication and dissemination of high-quality research and thought-provoking articles.