Ming-Yuan Victor Chao, Ching-Hsiu Peng, Fu-Pang Chang, Yi-Chun Wang
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引用次数: 0
Abstract
The emergence of glomerular diseases following COVID-19 vaccination, particularly with mRNA vaccines, has sparked significant interest in the scientific community. We present the genetic analysis of a case involving a 51-year-old female who developed C3 glomerulopathy following her 3rd dose of the mRNA-1273 (Moderna) COVID-19 vaccine. Through comprehensive whole-genome exome sequencing, we identified a missense mutation in the SLC12A3 gene, along with other genetic variations, which may provide insights into the molecular mechanisms underpinning vaccine-associated glomerulopathies. This case underscores the importance of exploring genetic predispositions when encountering adverse reactions to mRNA vaccines, particularly those affecting the complement pathway and glomerulopathies.
期刊介绍：
Clinical Nephrology appears monthly and publishes manuscripts containing original material with emphasis on the following topics: prophylaxis, pathophysiology, immunology, diagnosis, therapy, experimental approaches and dialysis and transplantation.
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