Treatment of Autoimmune Enteropathy With Vedolizumab.

IF 0.6 Q4 GASTROENTEROLOGY & HEPATOLOGY

ACG Case Reports Journal Pub Date : 2025-05-30 eCollection Date: 2025-06-01 DOI:10.14309/crj.0000000000001716

Tara Alleyasin, Evan Wilder, Warren Reidel, Emma Du, Quan M Nhu

引用次数: 0

Abstract

Autoimmune enteropathy (AIE) is a rare condition characterized by immune-mediated villous atrophy with associated chronic diarrhea. In this case, a 34-year-old man with AIE was treated with vedolizumab, an anti-ɑ4b7 integrin that inhibits intestinal lymphocyte trafficking, after initial treatments with prednisone, open-capsule budesonide, azathioprine, infliximab, and adalimumab showed minimal response. Vedolizumab resulted in moderate symptomatic and histological improvement but was discontinued due to possible drug-induced liver injury. This case suggests the potential therapeutic efficacy of vedolizumab in treating AIE, though more research is needed.

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Vedolizumab治疗自身免疫性肠病

自身免疫性肠病（AIE）是一种罕见的疾病，其特征是免疫介导的绒毛萎缩并伴有慢性腹泻。在这个病例中，一名34岁的AIE患者在最初用强的松、开放胶囊布地奈德、硫唑嘌呤、英夫利昔单抗和阿达木单抗治疗后，接受了维多单抗治疗，维多单抗是一种抑制肠道淋巴细胞运输的抗4b7整合素。Vedolizumab导致中度症状和组织学改善，但由于可能的药物性肝损伤而停药。该病例提示vedolizumab治疗AIE的潜在疗效，尽管还需要更多的研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACG Case Reports Journal GASTROENTEROLOGY & HEPATOLOGY-

自引率

14.30%

发文量

170

审稿时长

12 weeks

期刊介绍： ACG Case Reports Journal is a peer-reviewed, open-access publication that provides GI and hepatology fellows, private practice clinicians, and other healthcare providers an opportunity to share interesting case reports with their peers and with leaders in the field. ACG Case Reports Journal publishes case reports, images, videos and letters to the editor in all topics of gastroenterology and hepatology, including: Biliary Colon Endoscopy Esophagus Functional Bowel Disorders Inflammatory Bowel Disease Liver Nutrition and Obesity Pancreas Pathology Pediatric Small Bowel Stomach.