Asymptomatic SARS-CoV-2 Infection: Association Involving the HLA-B*15 Allele Group in Brazilian Individuals

IF 5.9 4区医学 Q2 CELL BIOLOGY

HLA Pub Date : 2025-06-01 DOI:10.1111/tan.70262

Christiane Maria Ayo, Henrique Magalhães, Marcos Paulo Miola, Cinara Cássia Brandão, Maurício Lacerda Nogueira, Cássia Fernanda Estofolete, Victor Hugo de Souza, Jeane Eliete Laguila Visentainer, Luiz Carlos de Mattos

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Abstract

The aim of this study was to investigate the influence of HLA-A, -B and -C polymorphisms on the clinical course of SARS-CoV-2 infection and on the progression of COVID-19 in a population from southeastern Brazil. This study included 478 unvaccinated individuals. Of these, 369 were hospitalised with critical/severe (n = 309) or moderate/mild (n = 60) symptoms, and 109 were asymptomatic. The control group consisted of 150 volunteer bone marrow donors, recruited in the pre-pandemic period. The HLA-B*15 allele group (adjusted p value < 0.001) was associated with a protective factor against symptomatic infection. Investigating the effects of the distribution of HLA alleles on susceptibility and resistance to SARS-CoV-2 may provide a better understanding of the clinical course of infection in different geographical regions.

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巴西无症状SARS-CoV-2感染：与HLA-B*15等位基因群的关联

本研究的目的是调查巴西东南部人群中HLA-A、-B和-C多态性对SARS-CoV-2感染临床病程和COVID-19进展的影响。这项研究包括478名未接种疫苗的个体。其中，369人因危重/重度（n = 309）或中度/轻度（n = 60）症状住院，109人无症状。对照组由150名志愿骨髓捐赠者组成，他们是在大流行前时期招募的。HLA-B*15等位基因组（调整p值<； 0.001）与预防症状性感染的保护因素相关。研究HLA等位基因分布对SARS-CoV-2易感和耐药的影响，可以更好地了解不同地理区域感染的临床过程。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

HLA Immunology and Microbiology-Immunology

CiteScore

3.00

自引率

28.80%

发文量

368

期刊介绍： HLA, the journal, publishes articles on various aspects of immunogenetics. These include the immunogenetics of cell surface antigens, the ontogeny and phylogeny of the immune system, the immunogenetics of cell interactions, the functional aspects of cell surface molecules and their natural ligands, and the role of tissue antigens in immune reactions. Additionally, the journal covers experimental and clinical transplantation, the relationships between normal tissue antigens and tumor-associated antigens, the genetic control of immune response and disease susceptibility, and the biochemistry and molecular biology of alloantigens and leukocyte differentiation. Manuscripts on molecules expressed on lymphoid cells, myeloid cells, platelets, and non-lineage-restricted antigens are welcomed. Lastly, the journal focuses on the immunogenetics of histocompatibility antigens in both humans and experimental animals, including their tissue distribution, regulation, and expression in normal and malignant cells, as well as the use of antigens as markers for disease.