The Peroxidation of Lipids, Cellular Senescence and Aging.

Abstract

The inducers of cellular senescence as a determinant in organismal aging are complex and likely driven by a combination of hormonal and metabolic factors. Lipids have recently been implicated as inducers of cellular senescence in vitro and in vivo across human and animal models and more directly, the electrophilic products of lipid peroxidation have been shown in a number of systems to initiate the senescence program. This review summarizes recent research at the interface of lipid biology and senescence. The review will emphasize the types of electrophilic lipids that induce senescence and how lipid scavengers are used to alleviate senescence burden and combat age-related disease.