Impact of dairy intake on circulating fatty acids and associations with blood pressure: A randomized crossover trial.

IF 3.3 3区医学 Q2 CARDIAC & CARDIOVASCULAR SYSTEMS

Nutrition Metabolism and Cardiovascular Diseases Pub Date : 2025-04-30 DOI:10.1016/j.numecd.2025.104112

Hana Arghavani, Jean-François Bilodeau, Iwona Rudkowska

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引用次数: 0

Abstract

Background and aims: This study aimed to investigate the effects of high and adequate dairy intake (>4, 2-3 serving/day, respectively) on circulating fatty acids (FAs) and their associations with blood pressure (BP).

Methods and results: A randomized crossover clinical trial was conducted with 27 participants (8 women, 19 men) at the CHU de Québec-Université Laval Research Center. Participants were assigned to either a high-dairy (HD) or adequate-dairy (AD) diet for six weeks, followed by a six-week washout period before crossing over. Plasma phospholipid-bound FAs were analyzed using gas chromatography, and BP and arterial stiffness were measured at each visit. Partial correlation analyses, generalized linear mixed models and machine learning techniques were employed to analyze the data. Pentadecanoic acid (15:0) and heptadecanoic acid (17:0) were positively correlated with dairy intake and showed increases after the HD. Palmitic acid (16:0) and total saturated FAs were positively associated with systolic (SBP) and diastolic (DBP), while 17:0 was inversely associated with diastolic BP.

Conclusions: HD was associated with increased 15:0 and 17:0. Notably, 17:0 had an inverse association with diastolic BP, while 16:0 was positively linked. These findings highlight the importance of dietary strategies that incorporate specific FAs to enhance cardiovascular health.

Registration number: NCT02961179.

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乳制品摄入对循环脂肪酸的影响及其与血压的关系：一项随机交叉试验。

背景和目的：本研究旨在探讨高和充足的乳制品摄入量（分别为4,2 -3份/天）对循环脂肪酸（FAs）的影响及其与血压（BP）的关系。方法和结果：在华中师范大学-拉瓦尔大学研究中心进行了一项随机交叉临床试验，共有27名参与者（8名女性，19名男性）。参与者被分配到高乳制品（HD）或足乳制品（AD）饮食六周，然后在跨越之前有六周的洗脱期。用气相色谱法分析血浆磷脂结合FAs，并在每次访问时测量血压和动脉硬度。采用偏相关分析、广义线性混合模型和机器学习技术对数据进行分析。十五烷酸（15:0）和十七烷酸（17:0）与乳制品摄入量呈正相关，并在HD后有所增加。棕榈酸（16:0）和总饱和脂肪酸与收缩压（SBP）和舒张压（DBP）呈正相关，而17:0与舒张压呈负相关。结论：HD与15:0和17:0升高有关。值得注意的是，17:0与舒张压呈负相关，而16:0与舒张压呈正相关。这些发现强调了纳入特定FAs的饮食策略对增强心血管健康的重要性。注册号：NCT02961179。

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来源期刊

Nutrition Metabolism and Cardiovascular Diseases 医学-内分泌学与代谢

CiteScore

6.80

自引率

2.60%

发文量

332

审稿时长

57 days

期刊介绍： Nutrition, Metabolism & Cardiovascular Diseases is a forum designed to focus on the powerful interplay between nutritional and metabolic alterations, and cardiovascular disorders. It aims to be a highly qualified tool to help refine strategies against the nutrition-related epidemics of metabolic and cardiovascular diseases. By presenting original clinical and experimental findings, it introduces readers and authors into a rapidly developing area of clinical and preventive medicine, including also vascular biology. Of particular concern are the origins, the mechanisms and the means to prevent and control diabetes, atherosclerosis, hypertension, and other nutrition-related diseases.