ExSPECKt the unexpected: NLRP3-caspase-8-dependent cell death in RBCs

IF 45.5 1区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cell Pub Date : 2025-05-29 DOI:10.1016/j.cell.2025.04.033

Rebecca E. Tweedell, Thirumala-Devi Kanneganti

引用次数: 0

Abstract

Red blood cell (RBC) lysis can cause morbidity and mortality. However, the molecular mechanisms underlying RBC lysis are not fully characterized, limiting therapeutic options. In this issue of Cell, Chen et al. identify a crucial role for the NLRP3-ASC-caspase-8 complex in driving programmed lytic cell death in RBCs.

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意想不到的：nlrp3 -caspase-8依赖性红细胞细胞死亡

红细胞（RBC）溶解可引起发病率和死亡率。然而，红细胞溶解的分子机制尚未完全确定，限制了治疗选择。在这一期的《细胞》杂志上，Chen等人发现NLRP3-ASC-caspase-8复合物在推动红细胞程序性溶解性细胞死亡中起着至关重要的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cell 生物-生化与分子生物学

CiteScore

110.00

自引率

0.80%

发文量

396

审稿时长

2 months

期刊介绍： Cells is an international, peer-reviewed, open access journal that focuses on cell biology, molecular biology, and biophysics. It is affiliated with several societies, including the Spanish Society for Biochemistry and Molecular Biology (SEBBM), Nordic Autophagy Society (NAS), Spanish Society of Hematology and Hemotherapy (SEHH), and Society for Regenerative Medicine (Russian Federation) (RPO). The journal publishes research findings of significant importance in various areas of experimental biology, such as cell biology, molecular biology, neuroscience, immunology, virology, microbiology, cancer, human genetics, systems biology, signaling, and disease mechanisms and therapeutics. The primary criterion for considering papers is whether the results contribute to significant conceptual advances or raise thought-provoking questions and hypotheses related to interesting and important biological inquiries. In addition to primary research articles presented in four formats, Cells also features review and opinion articles in its "leading edge" section, discussing recent research advancements and topics of interest to its wide readership.