Decoupling sequence and structure

IF 38.1 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nature reviews. Chemistry Pub Date : 2025-05-29 DOI:10.1038/s41570-025-00726-2

Chuanliu Wu

引用次数: 0

Abstract

In 1961, it was demonstrated that the enzyme ribonuclease can correctly fold upon oxidation in air from a fully reduced and denatured polypeptide chain. Since then, the principles that govern the oxidative folding of polypeptide chains have been elucidated, and our ability to control this process has advanced significantly.

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解耦序列与结构

1961年，研究人员证明，核糖核酸酶可以从完全还原和变性的多肽链在空气中氧化后正确折叠。从那时起，控制多肽链氧化折叠的原理已经阐明，我们控制这一过程的能力也有了显著的进步。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature reviews. Chemistry Chemical Engineering-General Chemical Engineering

CiteScore

52.80

自引率

0.80%

发文量

期刊介绍： Nature Reviews Chemistry is an online-only journal that publishes Reviews, Perspectives, and Comments on various disciplines within chemistry. The Reviews aim to offer balanced and objective analyses of selected topics, providing clear descriptions of relevant scientific literature. The content is designed to be accessible to recent graduates in any chemistry-related discipline while also offering insights for principal investigators and industry-based research scientists. Additionally, Reviews should provide the authors' perspectives on future directions and opinions regarding the major challenges faced by researchers in the field.