Mitochondrial DNA transfer between malignant cells and T lymphocytes shapes the cancer-immunity dialogue.

IF 6.5 2区医学 Q1 IMMUNOLOGY

Oncoimmunology Pub Date : 2025-12-01 Epub Date: 2025-05-28 DOI:10.1080/2162402X.2025.2512109

Liwei Zhao, Peng Liu, Oliver Kepp, Guido Kroemer

引用次数: 0

Abstract

Nonmutated mitochondrial DNA (mtDNA) from T lymphocytes can be incorporated into cancer cells bearing mutated mtDNA to repair their bioenergetic deficiency. However, a recent paper by Ikeda et al. indicates that mutated mtDNA from malignant cells can also be transferred into tumor-infiltrating T lymphocytes to subvert their function in cancer immunosurveillance.

查看原文本刊更多论文

恶性细胞和T淋巴细胞之间的线粒体DNA转移形成了癌症免疫对话。

来自T淋巴细胞的非突变线粒体DNA （mtDNA）可以被整合到携带突变mtDNA的癌细胞中，以修复其生物能量缺乏。然而，最近Ikeda等人的一篇论文指出，来自恶性细胞的突变mtDNA也可以转移到肿瘤浸润的T淋巴细胞中，从而破坏其在癌症免疫监视中的功能。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Oncoimmunology ONCOLOGYIMMUNOLOGY-IMMUNOLOGY

CiteScore

12.50

自引率

2.80%

发文量

276

审稿时长

24 weeks

期刊介绍： OncoImmunology is a dynamic, high-profile, open access journal that comprehensively covers tumor immunology and immunotherapy. As cancer immunotherapy advances, OncoImmunology is committed to publishing top-tier research encompassing all facets of basic and applied tumor immunology. The journal covers a wide range of topics, including: -Basic and translational studies in immunology of both solid and hematological malignancies -Inflammation, innate and acquired immune responses against cancer -Mechanisms of cancer immunoediting and immune evasion -Modern immunotherapies, including immunomodulators, immune checkpoint inhibitors, T-cell, NK-cell, and macrophage engagers, and CAR T cells -Immunological effects of conventional anticancer therapies.