[Research progress on techniques for detection of tick-borne encephalitis virus infections].

Q3 Medicine

中国血吸虫病防治杂志 Pub Date : 2025-02-28 DOI:10.16250/j.32.1915.2024191

Z Liu, H Xie, X Sun, T Xia, J Guo

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引用次数: 0

Abstract

Tick-borne encephalitis is a central nervous system disease caused by infections with tick-borne pathogens, which is characterized by severe clinical symptoms, multiple sequelae, and a high fatality rate. Currently, there is no cure for tick-borne encephalitis. Tick-borne encephalitis virus (TBEV) is the most common pathogen of tick-borne encephalitis. Therefore, rapid and accurate detection of TBEV contributes to reducing the mortality of tick-borne encephalitis, improving patients' prognosis, and reducing the risk of TBEV transmission. The currently available serological tests for detection of TBEV infections mainly include neutralization test, enzyme-linked immunosorbent assay (ELISA), immunofluorescence assay, and nucleic acid tests mainly include polymerase chain reaction (PCR), loop-mediated isothermal amplification (LAMP), reverse transcription polymerase spiral reaction, clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated proteins (Cas)-based assays. This review summarizes the progress of researches on serological and nucleic acid tests for detection of TBEV infections, so as to provide insights into prevention and control of tick-borne encephalitis.

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蜱传脑炎病毒感染检测技术研究进展

蜱传脑炎是一种由蜱传病原体感染引起的中枢神经系统疾病，临床症状严重，后遗症多，病死率高。目前，还没有治愈蜱传脑炎的方法。蜱传脑炎病毒（TBEV）是蜱传脑炎最常见的病原体。因此，快速准确地检测出脑炎病毒有助于降低蜱传脑炎的死亡率，改善患者预后，降低脑炎病毒传播的风险。目前可用的检测TBEV感染的血清学检测主要有中和试验、酶联免疫吸附试验（ELISA）、免疫荧光试验，核酸检测主要有聚合酶链反应（PCR）、环介导等温扩增（LAMP）、逆转录聚合酶螺旋反应、聚集规律间隔短回文重复(CRISPR)/CRISPR相关蛋白（Cas）检测。本文就蜱传脑炎的血清学检测和核酸检测的研究进展进行综述，以期为蜱传脑炎的防治提供参考。

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来源期刊

中国血吸虫病防治杂志 Medicine-Medicine (all)

CiteScore

1.30

自引率

0.00%

发文量

7021

期刊介绍： Chinese Journal of Schistosomiasis Control (ISSN: 1005-6661, CN: 32-1374/R), founded in 1989, is a technical and scientific journal under the supervision of Jiangsu Provincial Health Commission and organised by Jiangsu Institute of Schistosomiasis Control. It is a scientific and technical journal under the supervision of Jiangsu Provincial Health Commission and sponsored by Jiangsu Institute of Schistosomiasis Prevention and Control. The journal carries out the policy of prevention-oriented, control-oriented, nationwide and grassroots, adheres to the tenet of scientific research service for the prevention and treatment of schistosomiasis and other parasitic diseases, and mainly publishes academic papers reflecting the latest achievements and dynamics of prevention and treatment of schistosomiasis and other parasitic diseases, scientific research and management, etc. The main columns are Guest Contributions, Experts‘ Commentary, Experts’ Perspectives, Experts' Forums, Theses, Prevention and Treatment Research, Experimental Research, The main columns include Guest Contributions, Expert Commentaries, Expert Perspectives, Expert Forums, Treatises, Prevention and Control Studies, Experimental Studies, Clinical Studies, Prevention and Control Experiences, Prevention and Control Management, Reviews, Case Reports, and Information, etc. The journal is a useful reference material for the professional and technical personnel of schistosomiasis and parasitic disease prevention and control research, management workers, and teachers and students of medical schools. 　　 The journal is now included in important domestic databases, such as Chinese Core List (8th edition), China Science Citation Database (Core Edition), China Science and Technology Core Journals (Statistical Source Journals), and is also included in MEDLINE/PubMed, Scopus, EBSCO, Chemical Abstract, Embase, Zoological Record, JSTChina, Ulrichsweb, Western Pacific Region Index Medicus, CABI and other international authoritative databases.