Some general principles of riboswitch structure and interactions with small-molecule ligands.

IF 7.2 2区生物学 Q1 BIOPHYSICS

Quarterly Reviews of Biophysics Pub Date : 2025-05-28 DOI:10.1017/S0033583525100012

Lin Huang, David M J Lilley

引用次数: 0

Abstract

Riboswitches are RNA elements with a defined structure found in noncoding sections of genes that allow the direct control of gene expression by the binding of small molecules functionally related to the gene product. In most cases, this is a metabolite in the same (typically biosynthetic) pathway as an enzyme (or transporter) encoded by the gene that is controlled. The structures of many riboswitches have been determined and this provides a large database of RNA structure and ligand binding. In this review, we extract general principles of RNA structure and the manner or ligand binding from this resource.

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核开关结构和与小分子配体相互作用的一般原理。

核糖开关是一种结构明确的RNA元件，存在于基因的非编码部分，通过结合与基因产物功能相关的小分子，可以直接控制基因表达。在大多数情况下，这是一种代谢产物，与受控制基因编码的酶（或转运蛋白）具有相同的（通常是生物合成的）途径。许多核糖开关的结构已经被确定，这提供了一个RNA结构和配体结合的大数据库。在这篇综述中，我们从这些资源中提取了RNA结构的一般原理和配体结合的方式。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Quarterly Reviews of Biophysics 生物-生物物理

CiteScore

12.90

自引率

1.60%

发文量

期刊介绍： Quarterly Reviews of Biophysics covers the field of experimental and computational biophysics. Experimental biophysics span across different physics-based measurements such as optical microscopy, super-resolution imaging, electron microscopy, X-ray and neutron diffraction, spectroscopy, calorimetry, thermodynamics and their integrated uses. Computational biophysics includes theory, simulations, bioinformatics and system analysis. These biophysical methodologies are used to discover the structure, function and physiology of biological systems in varying complexities from cells, organelles, membranes, protein-nucleic acid complexes, molecular machines to molecules. The majority of reviews published are invited from authors who have made significant contributions to the field, who give critical, readable and sometimes controversial accounts of recent progress and problems in their specialty. The journal has long-standing, worldwide reputation, demonstrated by its high ranking in the ISI Science Citation Index, as a forum for general and specialized communication between biophysicists working in different areas. Thematic issues are occasionally published.