Photo- and Copper-Catalyzed Enantioselective Oxidation of Benzylic C(sp3)–H Bonds

IF 14.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Journal of the American Chemical Society Pub Date : 2025-05-26 DOI:10.1021/jacs.5c04142

Fu Li, Xian-Ming Liu, Jia-Bin Pan, Ling Dai, Yin Yang, Li-Jun Xiao, Chao Fan, Qi-Lin Zhou

引用次数: 0

Abstract

Here, we report a photo- and copper-catalyzed enantioselective oxidation of benzylic C(sp³)–H bonds using N-hydroxyphthalimide as the oxygenated reagent. The reaction proceeds under mild conditions and does not require excess substrates or oxidants. The oxidation products can be readily transformed into chiral benzylic alcohols or hydroxylamines. Preliminary mechanism studies suggest that the oxidation reaction proceeds via a free radical mechanism.

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光催化和铜催化对映选择性氧化苯基C(sp3) - h键

在这里，我们报道了用n -羟基邻苯二胺作为氧化试剂，光和铜催化对苯基C(sp3) -h键的对映选择性氧化。反应在温和的条件下进行，不需要过量的底物或氧化剂。氧化产物可以很容易地转化为手性苯基醇或羟胺。初步机理研究表明，氧化反应是通过自由基机制进行的。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of the American Chemical Society 化学-化学综合

CiteScore

24.40

自引率

6.00%

发文量

2398

审稿时长

1.6 months

期刊介绍： The flagship journal of the American Chemical Society, known as the Journal of the American Chemical Society (JACS), has been a prestigious publication since its establishment in 1879. It holds a preeminent position in the field of chemistry and related interdisciplinary sciences. JACS is committed to disseminating cutting-edge research papers, covering a wide range of topics, and encompasses approximately 19,000 pages of Articles, Communications, and Perspectives annually. With a weekly publication frequency, JACS plays a vital role in advancing the field of chemistry by providing essential research.