Pregnancy Outcomes in Hidradenitis Suppurativa Patients.

Abstract

Hidradenitis suppurativa is an autoinflammatory condition resulting in painful cysts, nodules, and sinus tracts in areas of high skin on skin contact. The microenvironment of affected tissues is high in pro-inflammatory cytokines and T-helper 17 cells. Other auto-inflammatory diseases, like psoriasis, have an enhanced risk of systemic inflammation and an elevated risk of spontaneous abortion. A cohort of pregnant patients from Cerner Health Facts® was identified using a Python adaptation of a validated pregnancy identification and classification algorithm. The HS population was identified among the pregnant population and was shown to be statistically significantly associated with outcome type by Chi square. A multinomial logistic regression also indicated a statistically significant increase in the odds of a pregnant patient having a spontaneous abortion over a live birth when controlling for thyroid disease, polycystic ovarian syndrome, antiphospholipid syndrome, other inflammatory diseases, and advanced maternal age.