[Suicidal ideation and behaviors: a transdiagnostic dimension for precision psychiatry].

IF 0.4 4区医学 Q4 MEDICINE, RESEARCH & EXPERIMENTAL

M S-medecine Sciences Pub Date : 2025-05-01 Epub Date: 2025-05-26 DOI:10.1051/medsci/2025066

Aiste Lengvenyte, Émilie Olié, Marion Leboyer, Philippe Courtet

引用次数: 0

Abstract

Suicidal thoughts and behaviors represent a transdiagnostic dimension independent of traditional psychiatric diagnoses. This specificity is supported by genetic studies, biomarkers, and preclinical research on endophenotypes associated with suicidal behaviors, such as impulsivity, anhedonia, and hopelessness. Clear mechanisms involving inflammation, the stress response, the serotonergic system, and neuroplasticity are emerging. Specific treatments, such as lithium and ketamine, target these mechanisms. The French Minds cohort of the PEPR PROPSY will identify the biological signatures and trajectories of this dimension using comprehensive multimodal approaches.

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[自杀意念和行为：精确精神病学的跨诊断维度]。

自杀的想法和行为是一个独立于传统精神病学诊断的跨诊断维度。遗传研究、生物标志物和与自杀行为相关的临床前研究支持了这种特异性，如冲动、快感缺乏和绝望。涉及炎症、应激反应、血清素能系统和神经可塑性的明确机制正在出现。特定的治疗，如锂和氯胺酮，针对这些机制。PEPR PROPSY的French Minds队列将使用综合多模式方法确定这一维度的生物学特征和轨迹。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

M S-medecine Sciences 医学-医学：研究与实验

CiteScore

0.80

自引率

14.30%

发文量

182

审稿时长

4-8 weeks

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