Treatment patterns and clinical outcomes of patients with HER2-positive T1micN0 breast cancer: a single-center analysis.

IF 7.6 2区医学 Q1 ONCOLOGY

NPJ Breast Cancer Pub Date : 2025-05-24 DOI:10.1038/s41523-025-00759-2

Celine Yeh, Rachel Han, Abha Kulkarni, Charlie White, Yuan Chen, Matthew G Hanna, Edi Brogi, Andrew D Seidman

引用次数: 0

Abstract

We conducted a retrospective analysis of 213 patients with HER2+ T1micN0 breast cancer. Patients with ≥5 foci of microinvasion received more aggressive treatment with higher rates of sentinel lymph node biopsy and adjuvant chemotherapy/HER2-targeted therapy (CT/H2TT) than patients with 1-4 foci. We did not detect significant differences in invasive disease-free survival between patients with 1-4 and ≥5 foci, or between patients with ≥5 foci who did and did not receive adjuvant CT/H2TT.

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her2阳性T1micN0乳腺癌患者的治疗模式和临床结果：单中心分析

我们对213例HER2+ T1micN0乳腺癌患者进行了回顾性分析。微侵袭灶≥5个的患者比1-4个灶的患者接受更积极的治疗，前哨淋巴结活检和辅助化疗/ her2靶向治疗（CT/H2TT）的比例更高。我们没有发现1-4和≥5个病灶的患者，或≥5个病灶的患者接受和未接受辅助CT/H2TT的侵袭性无病生存期有显著差异。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

NPJ Breast Cancer Medicine-Pharmacology (medical)

CiteScore

10.10

自引率

1.70%

发文量

122

审稿时长

9 weeks

期刊介绍： npj Breast Cancer publishes original research articles, reviews, brief correspondence, meeting reports, editorial summaries and hypothesis generating observations which could be unexplained or preliminary findings from experiments, novel ideas, or the framing of new questions that need to be solved. Featured topics of the journal include imaging, immunotherapy, molecular classification of disease, mechanism-based therapies largely targeting signal transduction pathways, carcinogenesis including hereditary susceptibility and molecular epidemiology, survivorship issues including long-term toxicities of treatment and secondary neoplasm occurrence, the biophysics of cancer, mechanisms of metastasis and their perturbation, and studies of the tumor microenvironment.