Photoexcited Copper-Catalyzed Difunctionalization of Alkenes for the Synthesis of 2,5-Diamino Acid Derivatives via Uncommon 1,2-Hydrogen Atom Transfer of Amidyl Radicals.

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-05-25 DOI:10.1021/acs.orglett.5c01633

Xue Zhang,Liulin Jiao,Ting Yuan,Jian Chen,Hongying Fan,Jinyu Hou,Guanghui Lv,Zhongzhen Yang,Yong Wu

引用次数: 0

Abstract

Compared with 1,5-hydrogen atom transfer (1,5-HAT) processes, 1,2-HAT processes have been reported less frequently. And, the synthesis of 2,5-diamino acid derivatives via a mild photocatalytic approach has not been reported yet. Herein, we report a photoexcited copper-catalyzed difunctionalization of alkenes for the synthesis of 2,5-diamino acid derivatives via uncommon 1,2-HAT. The potential synthetic merit of this reaction is proven through a scale-up reaction. Notably, this new protocol is successfully applied to obtain a series of 2,5-diamino acid derivatives.

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光激发铜催化烯烃双官能化合成2,5-二氨基酸衍生物少见的1,2-氢原子转移脒基。

与1,5-氢原子转移（1,5- hat）过程相比，1,2- hat过程的报道较少。并且，利用温和光催化方法合成2,5-二氨基酸衍生物尚未见报道。本文报道了一种光激发铜催化烯烃双官能化反应，通过1,2- hat合成了2,5-二氨基酸衍生物。通过放大反应证明了该反应的潜在合成价值。值得注意的是，该新方案成功地应用于获得一系列2,5-二氨基酸衍生物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.