Peritoneal membrane transport characteristics in patients undergoing peritoneal Dialysis are associated with systemic IL-8 levels

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine Pub Date : 2025-05-26 DOI:10.1016/j.cyto.2025.156965

Yufei Ye , Weiyan Huang , Xuelin Zhang , Xiaolu Bian , Haiyan Wang , Xinrui Liang , Xiaojuan Sun , Zhiyong Guo , Xueli Lai

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引用次数: 0

Abstract

Background

Several cytokine levels in dialysate, particularly interleukin-6 (IL-6), have been investigated as potential biomarkers for peritoneal solute transport rate (PSTR). However, studies examining the relationship between systemic cytokine levels and PSTR have yielded contradictory results. In this study, we aimed to assess 12 kinds of cytokines in serum and explore their potential relationship with peritoneal transport function.

Methods

Patients undergoing peritoneal dialysis (PD) from September 2022 to September 2024 were retrospectively analyzed at our PD center. The patients were categorized into fast and non-fast PSTR groups based on the 4-h dialysate creatinine /plasma creatinine ratio (D/P Cr). The systemic levels of 12 cytokines (IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, IL-17 A, TNF-α, IFN-α, and IFN-γ) in both groups were measured using flow cytometry and compared. The relationship between serum cytokine levels and baseline peritoneal transport status was analyzed by univariate and multivariate logistic regression analyses.

Results

A total of 284 patients were enrolled in this study. According to the D/P Cr, 171 patients (60.2 %) were classified as non-fast PSTR group, while 113 patients (39.8 %) were classified as fast PSTR group. Among the 12 cytokines analyzed, serum IL-8 exhibited a significant difference between the two groups (P = 0.01). IL-8/IL-10 and IL-12p70/IL-10 ratios were also significantly higher in fast PSTR group. In the subgroup of incident PD patients, multivariate analysis revealed that total cholesterol (OR 0.559, 95 % CI 0.323–0.966, P = 0.037) and serum IL-8 (OR 1.040, 95 % CI 1.006–1.075, P = 0.021) were significantly and independently associated with baseline fast PSTR.

Conclusion

The systemic IL-8 level is positively correlated with PSTR in patients undergoing PD, which may serve as an indicator of baseline peritoneal transport function.

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腹膜透析患者的腹膜转运特征与全身IL-8水平相关

透析液中的几种细胞因子水平，特别是白细胞介素-6 (IL-6)，已被研究作为腹膜溶质转运率（PSTR）的潜在生物标志物。然而，关于系统细胞因子水平与PSTR之间关系的研究得出了相互矛盾的结果。在这项研究中，我们旨在评估血清中的12种细胞因子，并探讨它们与腹膜运输功能的潜在关系。方法回顾性分析2022年9月至2024年9月在我院腹膜透析中心接受腹膜透析（PD）治疗的患者。根据4小时透析液肌酐/血浆肌酐比值（D/P Cr）将患者分为快速PSTR组和非快速PSTR组。采用流式细胞术检测两组患者体内12种细胞因子（IL-1β、IL-2、IL-4、IL-5、IL-6、IL-8、IL-10、IL-12p70、il - 17a、TNF-α、IFN-α、IFN-γ）水平，并进行比较。通过单因素和多因素logistic回归分析分析血清细胞因子水平与基线腹膜转运状态的关系。结果共纳入284例患者。根据D/P Cr，非快速PSTR组171例（60.2%），快速PSTR组113例（39.8%）。在12种细胞因子中，血清IL-8在两组间差异有统计学意义（P = 0.01）。快速PSTR组IL-8/IL-10和IL-12p70/IL-10比值也显著升高。在PD患者亚组中，多因素分析显示，总胆固醇（OR 0.559, 95% CI 0.323-0.966, P = 0.037）和血清IL-8 （OR 1.040, 95% CI 1.006-1.075, P = 0.021）与基线快速PSTR显著且独立相关。结论PD患者全身IL-8水平与PSTR呈正相关，可作为衡量PSTR基线水平的指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cytokine 医学-免疫学

CiteScore

7.60

自引率

2.60%

发文量

262

审稿时长

48 days

期刊介绍： The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.