NIH Chronic Graft-Versus-Host Disease Consensus Conference 2025 Update.

IF 3.6 3区医学 Q2 HEMATOLOGY

Transplantation and Cellular Therapy Pub Date : 2025-05-21 DOI:10.1016/j.jtct.2025.05.016

Stephanie J Lee, Kirsten M Williams, Stefanie Sarantopoulos, Carrie L Kitko, Corey Cutler, Joseph Pidala, Geoffrey R Hill, Zachariah DeFilipp, Hildegard T Greinix, Daniel Wolff, Sophie Paczesny, Geoffrey D E Cuvelier, Kirk R Schultz, Steven Z Pavletic

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Abstract

In 2020, the third NIH Consensus Development Project on Criteria for Chronic Graft-versus-Host Disease (GVHD) Clinical Trials was held with the goals of identifying gaps in understanding, prevention and treatment of chronic graft-versus-host disease (GVHD) and making actionable recommendations that would advance the field. An interim meeting was held in October 2024 to review progress on the 2020 recommendations. Each group was charged with reviewing their previous recommendations, assessing whether the field is on track to eventually achieve the goals, and considering whether recommendations should be modified in light of new data or insufficient progress. This manuscript summarizes the Working Groups' reports and helps define the research agenda for future studies in chronic GVHD. Overall, modest progress has been made on most initiatives. Some studies in progress will address key recommendations and results are eagerly anticipated.

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NIH慢性移植物抗宿主病共识会议2025更新。

2020年，第三个NIH慢性移植物抗宿主病（GVHD）临床试验标准共识发展项目举行，目标是确定慢性移植物抗宿主病（GVHD）的理解，预防和治疗方面的差距，并提出可操作的建议，以推进该领域。2024年10月举行了一次临时会议，审查2020年建议的进展情况。每个小组都负责审查他们以前的建议，评估该领域是否在最终实现目标的轨道上，并考虑是否应该根据新的数据或进展不足来修改建议。本文总结了工作组的报告，并有助于确定慢性GVHD未来研究的研究议程。总的来说，大多数倡议都取得了适度进展。正在进行的一些研究将涉及关键建议，人们热切期待结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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