The Functional Diversity of Chromatin-Associated RNA Binding Proteins in Transcriptional and Post-Transcriptional Regulation.

IF 6.4 2区 生物学 Q1 CELL BIOLOGY
Min Zhou, Jun Yang, Chuan Huang
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引用次数: 0

Abstract

RNA-binding proteins (RBPs) are a diverse class of proteins that interact with their target RNA molecules to regulate gene expression at the transcriptional and post-transcriptional levels. RBPs contribute to almost all aspects of RNA processing with sequence-specific, structure-specific, and nonspecific binding modes. Advances in our understanding of the mechanisms of RBP-mediated regulatory networks consisting of DNAs, RNAs, and protein complexes and the association between these networks and human diseases have been made very recently. Here, we discuss the "unconventional" functions of RBPs in transcriptional regulation by focusing on the cutting-edge investigations of chromatin-associated RBPs (ChRBPs). We briefly introduce examples of how ChRBPs influence the genomic features and molecular structures at the level of transcription. In addition, we focus on the post-transcriptional functions of various RBPs that regulate the biogenesis, transportation, stability control, and translation ability of circular RNA molecules (circRNAs). Lastly, we raise several questions about the clinical significance and potential therapeutic utility of disease-relevant RBPs.

染色质相关RNA结合蛋白在转录和转录后调控中的功能多样性。
RNA结合蛋白(rbp)是一类与靶RNA分子相互作用,在转录和转录后水平调控基因表达的蛋白质。rbp以序列特异性、结构特异性和非特异性结合模式参与RNA加工的几乎所有方面。最近,我们对rbp介导的由dna、rna和蛋白质复合物组成的调控网络的机制以及这些网络与人类疾病之间的关联的理解取得了进展。在这里,我们通过关注染色质相关rbp (chrbp)的前沿研究来讨论rbp在转录调控中的“非常规”功能。我们简要介绍了chrbp在转录水平上如何影响基因组特征和分子结构的例子。此外,我们还关注了各种rbp的转录后功能,这些rbp调节环状RNA分子(circRNAs)的生物发生、运输、稳定性控制和翻译能力。最后,我们对疾病相关rbp的临床意义和潜在的治疗应用提出了几个问题。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
14.80
自引率
4.10%
发文量
67
审稿时长
6-12 weeks
期刊介绍: WIREs RNA aims to provide comprehensive, up-to-date, and coherent coverage of this interesting and growing field, providing a framework for both RNA experts and interdisciplinary researchers to not only gain perspective in areas of RNA biology, but to generate new insights and applications as well. Major topics to be covered are: RNA Structure and Dynamics; RNA Evolution and Genomics; RNA-Based Catalysis; RNA Interactions with Proteins and Other Molecules; Translation; RNA Processing; RNA Export/Localization; RNA Turnover and Surveillance; Regulatory RNAs/RNAi/Riboswitches; RNA in Disease and Development; and RNA Methods.
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