Tumour plasticity and immune dynamics promote resistance to neo-adjuvant treatment

IF 28.5 1区医学 Q1 ONCOLOGY

Nature cancer Pub Date : 2025-05-22 DOI:10.1038/s43018-025-00954-x

引用次数: 0

Abstract

Esophageal adenocarcinoma (EAC) is challenging to treat because it frequently develops resistance to treatment. Multi-omic analyses of EAC during the course of treatment reveal phenotype plasticity of tumor cells and immune dynamics as mechanisms underlying therapy resistance that might have pharmacological relevance.

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肿瘤可塑性和免疫动力学促进对新辅助治疗的抵抗。

食管腺癌（EAC）的治疗具有挑战性，因为它经常产生耐药性。治疗过程中EAC的多组学分析揭示了肿瘤细胞的表型可塑性和免疫动力学是治疗耐药的机制，可能具有药理意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature cancer Medicine-Oncology

CiteScore

31.10

自引率

1.80%

发文量

129

期刊介绍： Cancer is a devastating disease responsible for millions of deaths worldwide. However, many of these deaths could be prevented with improved prevention and treatment strategies. To achieve this, it is crucial to focus on accurate diagnosis, effective treatment methods, and understanding the socioeconomic factors that influence cancer rates. Nature Cancer aims to serve as a unique platform for sharing the latest advancements in cancer research across various scientific fields, encompassing life sciences, physical sciences, applied sciences, and social sciences. The journal is particularly interested in fundamental research that enhances our understanding of tumor development and progression, as well as research that translates this knowledge into clinical applications through innovative diagnostic and therapeutic approaches. Additionally, Nature Cancer welcomes clinical studies that inform cancer diagnosis, treatment, and prevention, along with contributions exploring the societal impact of cancer on a global scale. In addition to publishing original research, Nature Cancer will feature Comments, Reviews, News & Views, Features, and Correspondence that hold significant value for the diverse field of cancer research.