{"title":"Recent applications of Cyrene as a chiral synthon.","authors":"Yu A Khalilova, L Kh Faizullina","doi":"10.1039/d5ob00642b","DOIUrl":null,"url":null,"abstract":"<p><p>Dihydrolevoglucosenone (Cyrene™) is a unique chiral molecule with great synthetic potential. Currently, Cyrene has been successfully used as a dipolar aprotonic solvent with green chemistry requirements, which is very important for both medicine and industry. There are several review articles on this topic, which we have referenced in this article. In this review, we describe the prospect of using Cyrene as a chiral molecule in organic synthesis, including an emphasis on the route to practically important objects based on it. The review presents chemical transformations of Cyrene by reactive centers (carbonyl and methylene groups, acetal center, anhydro bridge) with an eye to valuable chiral molecules and discusses the mechanism of some interesting transformations. We hope that the review will be useful to scientists working not only in organic but also in medicinal and polymer chemistry. The review summarizes the literature data for the last 10 years, with the rare exception of earlier works in view of the importance of using the published material.</p>","PeriodicalId":96,"journal":{"name":"Organic & Biomolecular Chemistry","volume":" ","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Organic & Biomolecular Chemistry","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1039/d5ob00642b","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, ORGANIC","Score":null,"Total":0}
引用次数: 0
Abstract
Dihydrolevoglucosenone (Cyrene™) is a unique chiral molecule with great synthetic potential. Currently, Cyrene has been successfully used as a dipolar aprotonic solvent with green chemistry requirements, which is very important for both medicine and industry. There are several review articles on this topic, which we have referenced in this article. In this review, we describe the prospect of using Cyrene as a chiral molecule in organic synthesis, including an emphasis on the route to practically important objects based on it. The review presents chemical transformations of Cyrene by reactive centers (carbonyl and methylene groups, acetal center, anhydro bridge) with an eye to valuable chiral molecules and discusses the mechanism of some interesting transformations. We hope that the review will be useful to scientists working not only in organic but also in medicinal and polymer chemistry. The review summarizes the literature data for the last 10 years, with the rare exception of earlier works in view of the importance of using the published material.
期刊介绍：
Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.
求助内容：
应助结果提醒方式：
京公网安备 11010802042870号
