Jacob Megreli, Leo Arkush, Estela Derazne, Arnon Afek, Gilad Twig, Bruria Ben-Zeev, Jaana Ahonniska Assa, Gali Heimer
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引用次数: 0
Abstract
Self-limited epilepsies of childhood are common and were considered benign. We aim to determine whether cognitive function in young adults who experienced epilepsy as children and are subsequently seizure-free and unmedicated differ from the general population. We report on a cross-sectional population-based study including 2,124,871 men and women aged 16-19 years. Participants > 5 years following the last seizure and > 2 years without anti-seizure medication (n = 3,452) had an odds ratio (OR) of having low cognitive function of 1.44 (95% confidence interval [CI] = 1.24-1.68, p < 0.001) using a multinominal regression model. Our results underscore the need to avoid the term "benign" in the classification of childhood epilepsies. ANN NEUROL 2025.
期刊介绍：
Annals of Neurology publishes original articles with potential for high impact in understanding the pathogenesis, clinical and laboratory features, diagnosis, treatment, outcomes and science underlying diseases of the human nervous system. Articles should ideally be of broad interest to the academic neurological community rather than solely to subspecialists in a particular field. Studies involving experimental model system, including those in cell and organ cultures and animals, of direct translational relevance to the understanding of neurological disease are also encouraged.
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