NHC/Pd Synergistically Catalyzed Direct Aerobic Oxidative Allylic Esterification of Aldehydes.

IF 5 1区化学 Q1 CHEMISTRY, ORGANIC

Organic Letters Pub Date : 2025-05-21 DOI:10.1021/acs.orglett.5c01392

Chhanda Debnath,Shikha Gandhi

引用次数: 0

Abstract

N-Heterocyclic carbene (NHC)-mediated aerobic oxidation of aldehydes has gained interest in recent years. However, its application in NHC/Pd synergistic catalysis has been unexplored. We have developed a strategy to synthesize allylic esters directly from aldehydes and Morita-Baylis-Hillman (MBH) carbonates using NHC/Pd synergistic (cooperative) catalysis under aerobic conditions. This transformation gives access to the selective formation of multifunctionalized E-alkenes by β-attack on the MBH carbonates. This catalytic system also allows the use of water as a cosolvent and air as the sole green oxidant.

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NHC/Pd协同催化醛类直接好氧烯丙基酯化反应。

近年来，n -杂环碳（NHC）介导的醛类有氧氧化引起了人们的广泛关注。然而，其在NHC/Pd协同催化中的应用尚未探索。在好氧条件下，利用NHC/Pd协同催化，直接从醛类和森田-贝利斯-希尔曼（MBH）碳酸盐合成烯丙基酯。这种转变使得通过β-攻击MBH碳酸盐选择性地形成多功能化e -烯烃。这种催化系统也允许使用水作为助溶剂和空气作为唯一的绿色氧化剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic Letters 化学-有机化学

CiteScore

9.30

自引率

11.50%

发文量

1607

审稿时长

1.5 months

期刊介绍： Organic Letters invites original reports of fundamental research in all branches of the theory and practice of organic, physical organic, organometallic,medicinal, and bioorganic chemistry. Organic Letters provides rapid disclosure of the key elements of significant studies that are of interest to a large portion of the organic community. In selecting manuscripts for publication, the Editors place emphasis on the originality, quality and wide interest of the work. Authors should provide enough background information to place the new disclosure in context and to justify the rapid publication format. Back-to-back Letters will be considered. Full details should be reserved for an Article, which should appear in due course.