Summitting CRISPR for Human Heritable Genome Editing.

IF 4 4区生物学 Q2 GENETICS & HEREDITY

CRISPR Journal Pub Date : 2025-05-21 DOI:10.1089/crispr.2025.0051

Françoise Baylis

引用次数: 0

Abstract

The ethical issues of human heritable genome editing have been discussed at international summits held since 2015. In this Perspective, I consider how the discussions evolved over three summits held in Washington, DC (2015), Hong Kong (2018), and London (2023). The significance of safety and efficacy, meanings of a moratorium, and place of broad societal consensus are traced through publications produced surrounding these summits. Looking ahead, I highlight the difference between two fundamentally distinct ethical questions: Is human heritable genome editing ethical? Can human heritable genome editing be done ethically?

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人类可遗传基因组编辑CRISPR峰会。

自2015年以来，人类可遗传基因组编辑的伦理问题一直在国际峰会上讨论。从这个角度来看，我考虑了在华盛顿特区（2015年）、香港（2018年）和伦敦（2023年）举行的三次峰会上的讨论是如何演变的。安全性和有效性的重要性，暂停的意义，以及广泛的社会共识的地方都可以通过围绕这些峰会产生的出版物来追踪。展望未来，我强调两个根本不同的伦理问题之间的区别：人类可遗传基因组编辑是否道德？人类可遗传的基因组编辑是否符合伦理？

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

CRISPR Journal Biochemistry, Genetics and Molecular Biology-Biotechnology

CiteScore

6.30

自引率

2.70%

发文量

期刊介绍： In recognition of this extraordinary scientific and technological era, Mary Ann Liebert, Inc., publishers recently announced the creation of The CRISPR Journal -- an international, multidisciplinary peer-reviewed journal publishing outstanding research on the myriad applications and underlying technology of CRISPR. Debuting in 2018, The CRISPR Journal will be published online and in print with flexible open access options, providing a high-profile venue for groundbreaking research, as well as lively and provocative commentary, analysis, and debate. The CRISPR Journal adds an exciting and dynamic component to the Mary Ann Liebert, Inc. portfolio, which includes GEN (Genetic Engineering & Biotechnology News) and more than 80 leading peer-reviewed journals.