miR-10b as a Clinical Marker and a Therapeutic Target for Metastatic Breast Cancer.

IF 2.8 4区 医学 Q3 ONCOLOGY
Technology in Cancer Research & Treatment Pub Date : 2025-01-01 Epub Date: 2025-05-21 DOI:10.1177/15330338251339256
Alan Halim, Bryan Kim, Elizabeth Kenyon, Anna Moore
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引用次数: 0

Abstract

Despite advances in cancer detection and treatment, metastatic breast cancer continues to carry a poor prognosis due to the lack of diagnostic and therapeutic resources that are specific to the metastatic process. MicroRNA-10b (miR-10b) is a small, noncoding RNA that is the focus of many studies due to its unique role as a driver of metastasis. The pathways it is involved in and the properties it confers have been reviewed previously and, collectively, are suggestive of the potential of miR-10b as a clinical marker and as a therapeutic target specific to metastatic disease. With the goal of application of our understanding of miR-10b to the clinic, in this mini-review, we highlight the studies that support the utility of miR-10b for these translational purposes.

Abstract Image

miR-10b作为转移性乳腺癌的临床标志物和治疗靶点
尽管在癌症检测和治疗方面取得了进展,但由于缺乏针对转移过程的诊断和治疗资源,转移性乳腺癌的预后仍然很差。MicroRNA-10b (miR-10b)是一种小的非编码RNA,由于其作为转移驱动因素的独特作用而成为许多研究的焦点。miR-10b参与的途径和它所赋予的特性已经在之前进行了综述,总的来说,这提示了miR-10b作为临床标志物和转移性疾病特异性治疗靶点的潜力。为了将我们对miR-10b的理解应用于临床,在这篇小型综述中,我们重点介绍了支持miR-10b用于这些转化目的的研究。
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来源期刊
CiteScore
4.40
自引率
0.00%
发文量
202
审稿时长
2 months
期刊介绍: Technology in Cancer Research & Treatment (TCRT) is a JCR-ranked, broad-spectrum, open access, peer-reviewed publication whose aim is to provide researchers and clinicians with a platform to share and discuss developments in the prevention, diagnosis, treatment, and monitoring of cancer.
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