Hepatoprotective diterpenes from the nodes of Pinus massoniana.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-05-21 DOI:10.1080/10286020.2025.2506527

Jia-Qi Chen, Ling-Zhi Zhang, Jie Ma, Chuang-Jun Li, Ying-Da Zang, Hua Sun, Dong-Ming Zhang

引用次数: 0

Abstract

Three new diterpenes, named pinusins D-F (1-3), were isolated from the Chinese medicine "Pini Lignum Nodi" (the dried tuberculate or branched nodes of Pinus massoniana), along with twelve known diterpenes. The structures of these new compounds were determined using detailed spectroscopic methods and ECD calculations. Compounds 4-15 displayed moderate hepatoprotective activity against H₂O₂-induced oxidative damage in HepG2 cells, while compounds 5-15 exhibited markedly enhanced efficacy -surpassing that of bicyclol (positive control).

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马尾松结中保肝二萜的研究。

从马尾松（Pini Lignum Nodi）中分离到3个新的二萜，命名为pinusins D-F(1-3)，以及12个已知的二萜。利用详细的光谱方法和ECD计算确定了这些新化合物的结构。化合物4-15对h2o2诱导的HepG2细胞氧化损伤表现出中度的肝保护活性，而化合物5-15表现出明显增强的功效，超过了双环醇（阳性对照）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.