Microwave Assisted Synthesis and Biological Studies of Phenothiazine-Based Imidazole Derivatives

Abstract

A series of tri-substituted imidazole derivatives were produced by combining ammonium acetate, 1,2-diketones, and alkyl substituted-10H-phenothiazine-3-carbaldehyde using KH₂PO₄ catalyst in both conventional and microwave irradiation method. All substances were tested for their antibacterial properties against the chosen gram positive and negative bacterial strains, all the produced compounds demonstrated good to moderate activity. Synthesized derivatives were evaluated for antioxidant studies and the results showed that the compound showed moderate to better activity.