Diagnostic value of blood coagulation index in obstetric antiphospholipid syndrome and its subtypes

IF 2.6 4区医学 Q1 MEDICINE, GENERAL & INTERNAL

Medicina Clinica Pub Date : 2025-05-22 DOI:10.1016/j.medcli.2025.106997

Xuan Qi , Xiaomeng Li , Yan Han , Lingyan Lei , Huifang Guo

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引用次数: 0

Abstract

Objective

To characterize blood coagulation index in obstetric antiphospholipid syndrome (OAPS) and its subtypes, analyzing correlations with immunological indices and diagnostic value.

Methods

A retrospective analysis was performed on OAPS patients treated at the Department of Rheumatology and Immunology, Second Hospital of Hebei Medical University, from September 2023 to March 2024. Healthy women of the same age range were matched for comparison.

Results

A total of 102 OAPS patients and 80 matched healthy controls were included. OAPS patients exhibited significantly lower levels of complement factors C3 and C4, coagulation factors V and VII activities, and protein S activity (p < 0.05). Conversely, they had elevated levels of anti-β2 glycoprotein I antibodies, platelets, thrombin–antithrombin complex (TAT), thromboelastographic reaction time (R), maximum amplitude (MA), clot formation index (CI), von Willebrand factor activity, coagulation factor VIII activity, and activated partial thromboplastin time (APTT) (p < 0.05). Among OAPS patients, criteria OAPS cases showed significantly higher anti-β2-GPI antibodies and anticardiolipin antibody levels (p < 0.01), with more spontaneous abortions and fetal deaths in this group (p < 0.01).

Conclusion

Correlations were found between immunological indices (ANA, complement C3, anti-β2-GPI) and coagulation indices (TAT, APTT). ANA, complement C3, anti-β2-GPI antibodies, and TAT were identified as risk factors for predicting OAPS. Blood coagulation and immune indices correlate in OAPS. Detecting these indices may provide diagnostic value for OAPS and its subtypes.

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凝血指标对产科抗磷脂综合征及其亚型的诊断价值

目的探讨产科抗磷脂综合征（OAPS）及其亚型的凝血指标特征，分析其与免疫学指标的相关性及诊断价值。方法回顾性分析河北医科大学第二医院风湿病与免疫科2023年9月至2024年3月收治的OAPS患者。同一年龄段的健康女性被配对进行比较。结果共纳入OAPS患者102例，健康对照80例。OAPS患者补体因子C3和C4、凝血因子V和VII活性及蛋白S活性水平明显降低(p <；0.05)。相反，他们的抗β2糖蛋白I抗体、血小板、凝血酶-抗凝血酶复合物（TAT）、血栓弹性反应时间(R)、最大振幅（MA）、血栓形成指数（CI）、血管性血友病因子活性、凝血因子VIII活性和活化的部分凝血活素时间（APTT）水平均升高(p <；0.05)。在OAPS患者中，标准OAPS患者抗β2- gpi抗体和抗心磷脂抗体水平显著升高(p <；0.01)，该组自然流产和胎儿死亡较多(p <；0.01)。结论免疫指标（ANA、补体C3、抗β2- gpi）与凝血指标（TAT、APTT）存在相关性。ANA、补体C3、抗β2- gpi抗体和TAT是预测OAPS的危险因素。OAPS患者的凝血指标与免疫指标相关。检测这些指标对OAPS及其亚型有一定的诊断价值。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medicina Clinica 医学-医学：内科

CiteScore

3.10

自引率

5.10%

发文量

295

审稿时长

22 days

期刊介绍： Medicina Clínica, fundada en 1943, es una publicación quincenal dedicada a la promoción de la investigación y de la práctica clínica entre los especialistas de la medicina interna, así como otras especialidades. Son características fundamentales de esta publicación el rigor científico y metodológico de sus artículos, la actualidad de los temas y, sobre todo, su sentido práctico, buscando siempre que la información sea de la mayor utilidad en la práctica clínica.