Development of myocardial perfusion imaging from coronary angiography for clinical application.

IF 1.5 Q3 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Radiological Physics and Technology Pub Date : 2025-05-17 DOI:10.1007/s12194-025-00917-y

Yuya Sekikawa, Yusuke Miyazaki, Takuya Sakaguchi

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引用次数: 0

Abstract

This study aimed to generate myocardial perfusion images from coronary angiography (CAG) using Patlak plot analysis and evaluate their effectiveness in detecting ischemia. Data from 29 patients were analyzed. Electrocardiogram-synchronized CAG images of the left coronary artery were registered and processed for pixel-wise Patlak analysis. Image generation succeeded in 18 cases (62%) and failed in 11 due to motion artifacts caused by irregular heartbeats, table panning, or deep breathing. The resulting images clearly distinguished ischemic from normal regions. Perfusion values were significantly lower in ischemic regions compared to normal regions (p < 0.001). Despite technical challenges and variability in patient conditions, this method enabled consistent identification of perfusion deficits. Enhancing image processing increases the success rate. This approach allows ischemia assessment directly from CAG data and supports timely treatment planning, contributing to improved diagnostic precision and clinical decision-making in selected cases.

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冠状动脉造影心肌灌注成像在临床应用中的进展。

本研究旨在利用Patlak图分析从冠状动脉造影（CAG）中生成心肌灌注图像，并评估其检测缺血的有效性。分析了29例患者的数据。对左冠状动脉的心电图同步CAG图像进行登记和处理，进行逐像素的Patlak分析。18例（62%）图像生成成功，11例由于不规则心跳、桌面平移或深呼吸引起的运动伪影而失败。所得到的图像清楚地区分了缺血和正常区域。缺血区灌注值明显低于正常区(p

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来源期刊

Radiological Physics and Technology RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING-

CiteScore

3.00

自引率

12.50%

发文量

期刊介绍： The purpose of the journal Radiological Physics and Technology is to provide a forum for sharing new knowledge related to research and development in radiological science and technology, including medical physics and radiological technology in diagnostic radiology, nuclear medicine, and radiation therapy among many other radiological disciplines, as well as to contribute to progress and improvement in medical practice and patient health care.