A wave of Thetis cells imparts tolerance to food antigens early in life.

IF 44.7 1区综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES

Science Pub Date : 2025-05-15 DOI:10.1126/science.adp0535

Vanja Cabric, Yollanda Franco Parisotto, Tyler Park, Blossom Akagbosu, Zihan Zhao, Yun Lo, Gayathri Shibu, Logan Fisher, Yoselin A Paucar Iza, Christina Leslie, Chrysothemis C Brown

引用次数: 0

Abstract

Within the intestine, peripherally-induced regulatory T (pTreg) cells play an essential role in suppressing inflammatory responses to food proteins. However, the identity of antigen-presenting cells (APC) that instruct food-specific pTreg cells is poorly understood. Here, we found that a subset of Thetis cells, TC IV, is required for food-specific pTreg cell differentiation. TC IV were almost exclusively present within mesenteric lymph nodes suggesting that the presence of TC IV underlies the phenomenon of oral tolerance. A wave of TC IV differentiation in the peri-weaning period was associated with a window of opportunity for enhanced pTreg generation in response to food antigens. Our findings indicate that TC IV may represent a therapeutic target for the treatment of food-associated allergic and inflammatory diseases.

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一波Thetis细胞在生命早期就赋予了对食物抗原的耐受性。

在肠道内，外周诱导的调节性T细胞（pTreg）在抑制对食物蛋白的炎症反应中发挥重要作用。然而，指导食物特异性pTreg细胞的抗原呈递细胞（APC）的身份尚不清楚。在这里，我们发现Thetis细胞的一个子集TC IV是食物特异性pTreg细胞分化所必需的。TC IV几乎完全存在于肠系膜淋巴结内，这表明TC IV的存在是口服耐受现象的基础。断奶前后的TC IV分化与对食物抗原反应增强pTreg生成的机会窗口有关。我们的研究结果表明，TC IV可能是治疗食物相关过敏性和炎症性疾病的治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Science 综合性期刊-综合性期刊

CiteScore

61.10

自引率

0.90%

发文量

审稿时长

2.1 months

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