Five new phenolics from the red resin of Dracaena cochinchinensis.

IF 1.3 3区医学 Q3 CHEMISTRY, APPLIED

Journal of Asian Natural Products Research Pub Date : 2025-05-15 DOI:10.1080/10286020.2025.2497279

Hong Shi, Nan-Pu Lin, Yong-Xian Cheng

引用次数: 0

Abstract

Five undescribed phenolics including three new flavonoids (1-3), one new flavone glycoside (4) and one neolignan (5), together with seven known compounds were isolated from the resins of Dracaena cochinchinensis (Chinese dragon's blood). Their structures were elucidated based on detailed spectroscopic analysis, including 1D, 2D NMR, mass spectrometry, and electronic circular dichroism (ECD) data analysis. In addition, biological evaluation of compounds 1-5 on anti-renal fibrotic activities were conducted, and the results showed that compounds 1a, 2, and 5 display anti-renal fibrotic activities in TFG-β induced NRK-52e cells.

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龙珠红树脂中5个新酚类物质。

从龙血树脂中分离到3个新的黄酮类化合物（1-3）、1个新的黄酮苷类化合物(4)和1个新木脂素类化合物(5)，以及7个已知化合物。基于详细的光谱分析，包括1D、2D NMR、质谱分析和电子圆二色性（ECD）数据分析，对它们的结构进行了阐明。此外，我们对化合物1 ~ 5的抗肾纤维化活性进行了生物学评价，结果表明化合物1a、2、5对TFG-β诱导的NRK-52e细胞具有抗肾纤维化活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Asian Natural Products Research 医学-药学

CiteScore

3.20

自引率

5.90%

发文量

审稿时长

2.3 months

期刊介绍： The Journal of Asian Natural Products Research (JANPR) publishes chemical and pharmaceutical studies in the English language in the field of natural product research on Asian ethnic medicine. The journal publishes work from scientists in Asian countries, e.g. China, Japan, Korea and India, including contributions from other countries concerning natural products of Asia. The journal is chemistry-orientated. Major fields covered are: isolation and structural elucidation of natural constituents (including those for non-medical uses), synthesis and transformation (including biosynthesis and biotransformation) of natural products, pharmacognosy, and allied topics. Biological evaluation of crude extracts are acceptable only as supporting data for pure isolates with well-characterized structures. All published research articles in this journal have undergone rigorous peer review, based on initial editor screening and anonymized refereeing by at least two expert referees.