Visible‐Light‐Induced C−H Amidation of (Hetero)arenes with Hypervalent Iodine(III) Reagents

IF 2.8 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2025-05-01 DOI:10.1002/ajoc.202400738

Xiaojuan Wang , He Wang , Zijia Ma , Yulong Ran , Ningning Liu , Yujia Wang , Jing Sun , Ran Sun , Lei Li

引用次数: 0

Abstract

A visible‐light‐promoted C−H amidation of (hetero)arenes with hypervalent iodine reagents has been successfully achieved with good yields. The high efficiency, broad substrate range and good functional group compatibility demonstrated the utility of the method. Moreover, this protocol was suitable for the late‐stage functionalization of natural products. Mechanistic studies have shown that the N‐centred saccharin radical mediates C−H amidation of arenes.

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可见光诱导高价碘（III）试剂对（杂）芳烃的C - H酰胺化反应

用高价碘试剂成功地实现了可见光促进（杂）芳烃的C - H酰胺化，收率高。高效率、宽衬底范围和良好的官能团相容性证明了该方法的实用性。此外，该方案适用于天然产物的后期功能化。机理研究表明，N中心糖精自由基介导芳烃的C - H酰胺化。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.