Continuous Flow N‐methylation of Morpholine and Aniline Catalyzed by Mesoporous Al‐SBA‐15

IF 2.8 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2025-05-01 DOI:10.1002/ajoc.202400760

Kelvin A. Sanoja‐López , Eliana Nope , Rafael Luque

引用次数: 0

Abstract

A continuous flow alkylation process is disclosed to synthesize N‐methylated derivatives of aniline and morpholine, compounds vital to the pharmaceutical, agrochemical, and polymer industries, using a mesoporous Al‐SBA‐15 catalyst. Conversions reached up to 99 % with almost complete selectivity for monoalkylated products under optimized temperature, pressure, and flow conditions. Compared to traditional batch methods, the continuous flow system enabled precise control of reaction parameters, significantly enhancing efficiency, reducing solvent use, and minimizing by‐product formation. The results demonstrate the process‘s feasibility for industrial applications, emphasizing its potential for more sustainable, cost‐effective large‐scale production and the role of continuous flow systems in developing safer, scalable, and environmentally friendly chemical processes.

查看原文本刊更多论文

介孔Al - SBA - 15催化的Morpholine和苯胺连续流动N -甲基化

使用介孔Al - SBA - 15催化剂，发明了一种连续流动烷基化工艺，用于合成苯胺和啉的N -甲基化衍生物，这些化合物对制药、农用化学品和聚合物工业至关重要。在优化的温度、压力和流动条件下，单烷基化产物的转化率高达99%，几乎完全具有选择性。与传统的批处理方法相比，连续流系统能够精确控制反应参数，显著提高效率，减少溶剂的使用，并最大限度地减少副产物的形成。结果证明了该工艺在工业应用上的可行性，强调了其在更可持续、更具成本效益的大规模生产中的潜力，以及连续流系统在开发更安全、可扩展和环保的化学工艺中的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.