Construction of 2‐(Trifluoromethyl)‐[1,2,4]Triazolo[1,5‐a]Quinoline Derivatives via Cycloaddition of N‐Amino Quinolinium Salts with CF3CN

IF 2.8 4区化学 Q1 CHEMISTRY, ORGANIC

Asian Journal of Organic Chemistry Pub Date : 2025-05-01 DOI:10.1002/ajoc.202500010

Zhezuo Chen , Peiqi Yang , Dr. Shouxiong Chen , Prof. Dr. Fafu Yang , Prof. Dr. Zhiqiang Weng

引用次数: 0

Abstract

A (3+2)‐cycloaddition of N‐amino quinolinium salts with in situ generated trifluoroacetonitrile is disclosed. The reaction affords access to structurally diverse 2‐(trifluoromethyl)‐[1,2,4]triazolo[1,5‐a]quinoline derivatives in good yields, utilizing 2,2,2‐trifluoroacetaldehyde O‐(aryl)oxime as precursor of trifluoroacetonitrile.

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N -氨基喹啉盐与CF3CN环加成法制备2‐（三氟甲基）‐[1,2,4]三唑[1,5‐a]喹啉衍生物

公开了N -氨基喹啉盐与原位生成的三氟乙腈的（3+2）环加成反应。该反应利用2,2,2 -三氟乙醛O -（芳基）肟作为三氟乙腈的前体，以高收率获得结构多样的2‐（三氟甲基）‐[1,2,4]三唑[1,5‐a]喹啉衍生物。

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来源期刊

Asian Journal of Organic Chemistry CHEMISTRY, ORGANIC-

CiteScore

4.70

自引率

3.70%

发文量

372

期刊介绍： Organic chemistry is the fundamental science that stands at the heart of chemistry, biology, and materials science. Research in these areas is vigorous and truly international, with three major regions making almost equal contributions: America, Europe and Asia. Asia now has its own top international organic chemistry journal—the Asian Journal of Organic Chemistry (AsianJOC) The AsianJOC is designed to be a top-ranked international research journal and publishes primary research as well as critical secondary information from authors across the world. The journal covers organic chemistry in its entirety. Authors and readers come from academia, the chemical industry, and government laboratories.